Journal of Clinical Immunology

, Volume 6, Issue 3, pp 234–241 | Cite as

High IgM antibody to human T-lymphotropic virus type I in systemic lupus erythematosus

  • Paul E. Phillips
  • S. Larrian Johnston
  • Lorne A. Runge
  • Janet L. Moore
  • Bernard J. Poiesz
Original Articles


Twenty-six percent of 53 systemic lupus erythematosus sera had high levels of IgM antibody to human T-lymphotropic virus Type I, significantly more than the 5% of normal controls. Neither IgG antibodies to Type I virus nor IgM or IgG antibodies to Type II virus were increased in lupus. Further analysis using competition immunoassay and Western blot techniques also suggested that the IgM Type I antibodies in lupus sera were directed against viral antigens but did not completely exclude a nonviral reaction. Other studies also have not found IgG antibodies to the Type I virus but have not tested for IgM antibodies. Our study suggests that human T-lymphotropic virus Type I or a related virus may be involved in the pathogenesis of some cases of systemic lupus erythematosus.

Key words

Human T-lymphotropic virus Type I systemic lupus erythematosus serum antibody 


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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Paul E. Phillips
    • 1
  • S. Larrian Johnston
    • 1
  • Lorne A. Runge
    • 1
  • Janet L. Moore
    • 1
  • Bernard J. Poiesz
    • 1
  1. 1.Departments of Medicine and MicrobiologyState University of New York—Upstate and Veterans Administration Medical CentersSyracuse

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