Advertisement

Journal of Clinical Immunology

, Volume 6, Issue 3, pp 234–241 | Cite as

High IgM antibody to human T-lymphotropic virus type I in systemic lupus erythematosus

  • Paul E. Phillips
  • S. Larrian Johnston
  • Lorne A. Runge
  • Janet L. Moore
  • Bernard J. Poiesz
Original Articles

Abstract

Twenty-six percent of 53 systemic lupus erythematosus sera had high levels of IgM antibody to human T-lymphotropic virus Type I, significantly more than the 5% of normal controls. Neither IgG antibodies to Type I virus nor IgM or IgG antibodies to Type II virus were increased in lupus. Further analysis using competition immunoassay and Western blot techniques also suggested that the IgM Type I antibodies in lupus sera were directed against viral antigens but did not completely exclude a nonviral reaction. Other studies also have not found IgG antibodies to the Type I virus but have not tested for IgM antibodies. Our study suggests that human T-lymphotropic virus Type I or a related virus may be involved in the pathogenesis of some cases of systemic lupus erythematosus.

Key words

Human T-lymphotropic virus Type I systemic lupus erythematosus serum antibody 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Phillips PE, Christian CL: Infectious agents in chronic rheumatic disease.In Arthritis and Allied Conditions, 10th ed, DJ McCarty (ed). Philadelphia, Lea & Febiger, 1985, pp 431–449Google Scholar
  2. 2.
    Rodnan GP, Schumacher HR (eds): Primer on the Rheumatic Diseases, 8th ed. Atlanta, Arthritis Foundation, 1983, pp 207–211Google Scholar
  3. 3.
    Poiesz B, Moore J, Merl S, Tomar, R, Zamkoff K, Davey F, Planas A, Gottlieb A, Runge L, Cowan BY, Reeves WG, Ehrlich G, Ruscetti FW, Hon T, Cabradilla CD, Comis R: Biology and epidemiology of HTLV.In Cancer Cells Vol 3. Human T-Cell Leukemia Viruses, R Gallo, M Essex, L Gross (eds). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1984, pp 237–247Google Scholar
  4. 4.
    Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T cell lymphoma. Proc Natl Acad Sci USA 77:7415–7419, 1980Google Scholar
  5. 5.
    Kalyanaraman VS, Sarangadaharan MG, Robert-Guroff M, Myoshi I, Blaney D, Golde D, Gallo R: A new subtype of human T-cell leukemia/lymphoma virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science 218:571–573, 1982Google Scholar
  6. 6.
    Burnette WN: “Western blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 112:195–203, 1981Google Scholar
  7. 7.
    Hawkes R, Niday E, Gordon J: A dot-immunobinding assay for monoclonal and other antibodies. Anal Biochem 119:142–147, 1982Google Scholar
  8. 8.
    Merl S, Kloster B, Moore J, Hulbell C, Tomar R, Davey F, Kalinowski D, Planas A, Ehrlich G, Clark D, Comis R, Poiesz B: Efficient transformation of previously activated and dividing T-lymphocytes by HTLV. Blood 64:967–974, 1984Google Scholar
  9. 9.
    Broder S, Gallo RC: A pathogenic retrovirus (HTLV-III) linked to AIDS. N Engl J Med 311:1292–1297, 1984Google Scholar
  10. 10.
    Rabson AB, Martin MA: Molecular organization of the AIDS retrovirus. Cell 40:477–480, 1985Google Scholar
  11. 11.
    Okamoto T, Tamura T, Takano T: Evidence in patients with SLE of the presence of antibodies against RNA-dependent DNA polymerase of baboon endogenous virus. Clin Exp Immunol 54:747–755, 1983Google Scholar
  12. 12.
    Halbert SP, Poiesz B, Friedman-Kien AE, Montagna R, Blattner WA, Anken M: Quantitative estimation of HTLV-I antibodies by a standardized ELISA in adult T cell leukemia and AIDS. J Clin Microbiol (in press)Google Scholar
  13. 13.
    Koike T, Kagami M, Takabayashi K, Maruyama N, Tomioka H, Yoshida S: Antibodies to human T cell leukemia virus are absent in patients with SLE. Arth Rheum 28:481–484, 1985Google Scholar
  14. 14.
    Kurata A, Katamine S, Fukuda T, Mine M, Ikari N, Kanazawa H, Matsunaga M, Eguchi K, Nagataki S: Production of a monoclonal antibody to a membrane antigen of human T-cell leukaemia virus (HTLV1/ATLV)-infected cell lines from a SLE patient; Serological analyses for HTLV1 infections in SLE patients. Clin Exp Immunol 62:65–74, 1985Google Scholar
  15. 15.
    McDougal JS, Kennedy MS, Kalyanaraman VS, McDuffie FC: Failure to demonstrate (cross-reacting) antibodies to human T lymphotropic viruses in patients with rheumatic diseases. Arth Rheum 28:1170–1174, 1985Google Scholar
  16. 16.
    Boumpas DT, Popovic M, Mann DL, Balow JE, Tsokos GC: Type C retroviruses of the human T cell leukemia family are not evident in patients with SLE. Arthritis Rheum 29:185–188, 1986Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Paul E. Phillips
    • 1
  • S. Larrian Johnston
    • 1
  • Lorne A. Runge
    • 1
  • Janet L. Moore
    • 1
  • Bernard J. Poiesz
    • 1
  1. 1.Departments of Medicine and MicrobiologyState University of New York—Upstate and Veterans Administration Medical CentersSyracuse

Personalised recommendations