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Synthesis and antihelminthic action of 1,3-cyclohexanedione derivatives containing branched aliphatic chains

Summary

1,3-Cyclohexanedione was alkylated with branched allyl bromides. The resulting 2-alkyl derivatives and their enol acetates possess antihelminthic activity. The enol acetate of 2-(3,7,11-trimethyl-2-dodecenyl)-1,3-cyclohexanedione was found to be the most active.

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Literature cited

  1. [1]

    I. N. Nazarov, B. P. Gusev and V. I. Gunar, Bull. Acad. Sci. USSR, Div. Chem. Sci. 1957, 1267.

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Gunar, V.I., Zav'yalov, S.I. & Krotov, A.I. Synthesis and antihelminthic action of 1,3-cyclohexanedione derivatives containing branched aliphatic chains. Russ Chem Bull 8, 334 (1959). https://doi.org/10.1007/BF00917387

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Keywords

  • Acetate
  • Bromide
  • Cyclohexanedione
  • Allyl
  • Enol