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Wound tissue respiratory burst and local microbial inflammation

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Local and systemic chemiluminescent (CL) response was measured in 32 patients with wound infection and in 27 patients with crush syndrome complicated by severe wound infection. The level of wound CL depends upon the local microbial concentration and the dynamics of wound healing. CL response of neutrophils in circulation was higher in higher local CL response, but extremely high wound microbial concentration (> 108 CFU/g) suppressed both local and systemic responses. No metabolic reserve was observed in wound tissue. Wound healing was characterized by changes in the mode of local CL response: from a prevalence of luminol-dependent (neutrophilic) CL to a prevalence of lucigenin-independent (macrophagal) CL.

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Dr. Tatiana Snastina was a “major scientist” in the Institute of Surgery when this study was done.

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Belotsky, S.M., Guzu, E.V., Karlov, V.A. et al. Wound tissue respiratory burst and local microbial inflammation. Inflammation 14, 663–668 (1990). https://doi.org/10.1007/BF00916369

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  • Public Health
  • Internal Medicine
  • Wound Healing
  • Wound Infection
  • Systemic Response