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Isotypes of surface immunoglobulin on B lymphocytes from patients with immune deficiency

Abstract

Peripheral blood lymphocytes from patients with antibody deficiency diseases (primarily agammaglobulinemia) were examined for the presence of B-lymphocyte subsets defined by surface immunoglobulin isotypes. The patients could be classified into one of four groups based upon the presence or absence of particular isotype-defined subsets. Patients with type I agammaglobulinemia lacked cells bearing surface IgG as well as IgD Igm+-bearing cells. Type II agammaglobulinemia had unusually large numbers of IgG-bearing cells, representing as many as 50% of the peripheral blood B lymphocytes, while other B-cell subsets were present in normal numbers. Type III agammaglobulinemia had apparently normal numbers of all B-cell subsets. Hyper IgM immunodeficiency lacked cells bearing surface IgG, but did have all three IgD/IgM-bearing B-cell subsets. This classification of patients based upon B-cell subsets present in peripheral blood directly correlates with previous functional studies of B cells from these patients. We suggest that abnormalin vitro function of cells from these patients results from abnormal populations of B cells in peripheral blood, which result from the underlying disease.

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Schwaber, J.F., Rosen, F.S. Isotypes of surface immunoglobulin on B lymphocytes from patients with immune deficiency. J Clin Immunol 2, 30–34 (1982). https://doi.org/10.1007/BF00915975

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Key words

  • B lymphocytes
  • immune deficiency
  • agammaglobulinemia
  • surface Ig isotypes