, Volume 14, Issue 3, pp 275–283 | Cite as

α2-Macroglobulin and fibrinogen modulate inflammatory edema in man

  • J. Van Gool
  • H. Van Vugt
  • E. De Bont
Original Articles


Animal experiments suggest that the response of acute-phase proteins (APPs) modulates the inflammatory reaction following tissue injury. To study this in man we investigated the relation between a number of APPs, including fibrinogen and α2-macroglobulin, and the inflammatory edema induced by a primary immunization against cholera, typhoid, and yellow fever. Vaccination induces a significant APP response; however, only α2-macroglobulin and fibrinogen were of importance to the amount of edema, measured 24 h after vaccination. High plasma levels of α2-macroglobulin strongly inhibit the amount of edema, whereas a high level of fibrinogen proved to be a stimulating factor. This holds both for the basal prevaccination levels and the postvaccination levels. The normal variation of the plasma concentration of these proteins in healthy subjects seems to be a determining factor to the amount of edema in this kind of injury.


Plasma Concentration Healthy Subject Animal Experiment Plasma Level Fibrinogen 
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  1. 1.
    Van Gool, J., N. C. J. J. Ladiges, I. de Nie andW. Boers. 1977. Inflammation inhibiting properties of rat foetoprotein (rat α2 macroglobulin), an acute phase reactant.Agents Actions (suppl.)2:141–161.Google Scholar
  2. 2.
    Ufkes, J. C. R., A. Zeegers andW. Boers. 1983. Inhibitory effects of BaSO4 on experimentally induced inflammation in the rat mediated by αM foetoprotein.Arch. Int. Pharamcodyn. Ther. 2:287–298.Google Scholar
  3. 3.
    Van Vugt, H., J. Van Gool andL. de Ridder. 1986. α2Macroglobulin of the rat an acute phase protein mitigates the early course of endotoxin shock.Brit. J. Exp. Path. 67:313–319.Google Scholar
  4. 4.
    Gehring, M. C., B. R. Shiels, W. Northemann, M. H. L. de Bruyn, Chen Chen Kan, A. C. Chain, D. J. Noonan andG. Fey. 1987. Sequence of rat liver α2macroglobulin and acute phase control of its messenger RNA.J. Biol. Chem. 262:446–454.Google Scholar
  5. 5.
    Marone, C., W. Flury, A. Montandon andH. Keller. 1987. Das verhalten von 16 serumeiweissfraktionen nach nierentransplantation.Klin. Wschr. 56:647–654.Google Scholar
  6. 6.
    Van Gool, J., 1983. Profiles of acute phase reactants and clinical significance of α2macroglobulin in acute hepatitis B.Inflammation. 7(3):227–289.Google Scholar
  7. 7.
    Wiseman, E. H. andYi-Han Chang. 1986. The role of fibrin in the inflammatory response to carrageenan.J. Pharmac. Exp. Therap. 159:206–209.Google Scholar
  8. 8.
    Documenta Geigy Wissenschaftliche Tabellen. 1980. CIBA-GEIGY, Basel.Google Scholar
  9. 9.
    Henry, J. B., 1979. Clinical Diagnosis and Management by Laboratory Methods 16th ed. W. B. Saunders, Philadelphia.Google Scholar
  10. 10.
    Colley, C. M., A. Fleck, A. W. Goode, B. Muller andM. A. Myers. 1983. Early time course of the acute phase protein response in man.J. Clin. Path. 36:203–207.Google Scholar
  11. 11.
    Raun, N. E., B. B. Moller, U. Back andJ. Gad. 1982. On individual reference intervals based on a longitudinal study of plasma proteins and lipids in healthy subjects and their possible clinical application.Clin. Chem. 28:294–300.Google Scholar
  12. 12.
    Lewis, D. A. 1984. Endogenous anti-inflammatory factors.Biochem. Pharm. 33(11):1705–1714.Google Scholar
  13. 13.
    Van Gool, J., H. van Vugt andI. de Nie. 1986. Acute phase reactants enhance CCl4 induced liver cirrhosis in the rat.Exp. Mol. Path. 44:157–168.Google Scholar
  14. 14.
    Van Gool, J., I. De Nie, J. Smit andF. M. J. Zuyderhoudt. 1986. Mechanisms by which acute phase proteins enhance development of liver fibrosis: Effects on collagenase and proly-l4-hydroxilase activity in the rat liver.Exp. Mol. Path. 45:160–170.Google Scholar
  15. 15.
    Ozeki, T., M. Kan, K. Iwaki andK. Ohunci. 1986. Orosomucoid as the accelerator of hepatic fibrosis.Brit. J. Exp. Path. 67:731–736.Google Scholar
  16. 16.
    Van Gool, J., N. C. J. J. Ladiges andW. Boers. 1982. Inhibition of polymorphonuclear leucocyte chemotaxis by α-macrofetoprotein, an acute phase reactant of the rat.Inflammation 6:127–135.Google Scholar
  17. 17.
    Van Gool, J., H. van Vugt andE. de Bont. 1989. Het effect van acute-fase eiwitten opontstekingsoedeem ten gevolge van vaccinatie.Ned. Tijdschr. Geneesk.133:822–827.Google Scholar
  18. 18.
    Becker, C. G. andP. C. Harpel. 1976.α 2Macroglobulin on human vascular endothelium.J. Exp. Med. 144:1–9.Google Scholar
  19. 19.
    Meade, T. W. 1987. The epidemiology of haemostatic and other variables in coronary artery disease.In Thrombosis and Haemostasis. M. Verstraete, J. Vermijlen, H. R. Lijnen and J. Amout, editors. Leuven University Press, Leuven. 37–55.Google Scholar
  20. 20.
    Meade, T. W., M. V. Vickers, S. G. Thompson andM. J. Seghatchian. 1985. The effect of physiological levels of fibrinogen on platelet aggregation.Thromb. Res. 38:527–534.Google Scholar
  21. 21.
    Higgs, G. A. andT. J. Williams, editors. 1985. Inflammatory mediators. V. C. H. Publishers, Deerfield Beach, Florida.Google Scholar
  22. 22.
    Wilson, G. S. and A.Miles, editors. 1975. Topley and Wilson's Principles of Bacteriology, Virology and Immunity. 6th ed; vol. 2. 1326–1329.Google Scholar

Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • J. Van Gool
    • 1
  • H. Van Vugt
    • 1
  • E. De Bont
    • 1
  1. 1.Laboratory of Experimental MedicineUniversity of Amsterdam Academic Medical CenterAZ AmsterdamThe Netherlands

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