The reaction of dialkyl N-dialkylphosphoramidites with alkyl esters ofα-amino acids leads to their transamidation.
The transamidation products undergo an isomerization reaction with alkyl halides.
The transamidation products add sulfur to the trivalent phosphorus.
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Grechkin, N.P., Nikonorova, L.K. New method of synthesizing N-alkoxycarbonylalkylphosphoramidites. Russ Chem Bull 16, 911–912 (1967). https://doi.org/10.1007/BF00915691
- Alkyl Halide