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Phagocyte chemotaxis in the perinatal period


Cross-sectional and limited sequential studies of neutrophil and monocyte chemotaxis were done using cells isolated from cord blood and peripheral blood of 2- to 6-day-old neonates and infants at 4 and 6 months of age. These studies show that cord blood phagocyte chemotaxis is comparable to adult values, whereas phagocyte chemotaxis at 2–6 days of age is significantly lower than adult (P<0.01) or cord (P<0.01) chemotaxis values. At 6 months of age, phagocyte chemotaxis is still low compared to adult values (P<0.01).

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Correspondence to Michael E. Miller.

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Raghunathan, R., Miller, M.E., Everett, S. et al. Phagocyte chemotaxis in the perinatal period. J Clin Immunol 2, 242–245 (1982).

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Key words

  • Chemotaxis
  • neutrophils
  • monocytes
  • cord blood
  • neonates
  • infants