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Relation of structure to physiological action for phosphorylated chloral hemiacetals

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Conclusions

  1. 1.

    By the reactions of chloral hemiacetals with dialkyl phosphorochloridites and dialkyl phosphorochloridates the corresponding phosphorous and phosphoric triesters were prepared.

  2. 2.

    The compounds obtained are biologically active.

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Literature cited

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    W. T. Sumerford and F. M. Cronie, J. Am. Chem. Soc,70, 448 (1948).

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    West German Patent 1,049,842 (1959); Chem. Zentr.,1959, 11663.

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    J. F. Reinhard, M. N. Lewis, R. J. Meltzer, and J. A. King, J. Am. Pharm. Assoc., Sci. Ed.,46, 359 (1957); Chem. Zentr.,1959, 2546.

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    Sh. Mamedov and G. Ya. Lerner, Azerb. Khim. Zh., No. 6, 87 (1961).

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    K. V. Nikonorov and É. A. Gurylev, Izv. Akad. Nauk SSSR, Ser. Khim.,1967, 1872.

  6. 6.

    K. V. Nikonorov, É. A. Gurylev, and A. V. Chernova, Izv. Akad. Nauk SSSR, Ser. Khim.,1968, 587.

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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 603–605, March, 1968.

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Nikonorov, K.V., Gurylev, É.A., Mertsalova, F.F. et al. Relation of structure to physiological action for phosphorylated chloral hemiacetals. Russ Chem Bull 17, 582–584 (1968). https://doi.org/10.1007/BF00911615

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Keywords

  • Chloral
  • Physiological Action
  • Phosphorochloridates
  • Phosphorochloridites
  • Phosphoric Triesters