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A new method for the synthesis of macrocyclic compounds

Communication 7. Preparation of macrocyclic ketolactones by intramolecular acylation

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Conclusions

  1. 1.

    A new method for the synthesis of macrocyclic ketolactones containing a thiophene ring has been developed.

  2. 2.

    The reductive desulfuration of macrocyclic ketolactones containing a thiophene ring has given ketoalkanolides, in particular that with a 14-membered ring the structure of which is close to that of the cyclic fragment of the natural macrolide antibiotics.

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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 566–572, March, 1968.

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Taits, S.Z., Alashev, F.D. & Gol'dfarb, Y.L. A new method for the synthesis of macrocyclic compounds. Russ Chem Bull 17, 550–554 (1968). https://doi.org/10.1007/BF00911609

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Keywords

  • Thiophene
  • Macrolide
  • Macrolide Antibiotic
  • Thiophene Ring
  • Macrocyclic Compound