It is shown that it is possible in principle to synthesize pyridine bases by the condensation of substituted 1-buten-3-yne (2-methyl-1-buten-3-yne) with ketones and ammonia over the catalyst Cd3(PO4/Al2O3, which considerably widens the possibilities of the method in synthesis.
The nature of the main products confirms the correctness of the mechanism proposed for this condensation in the case of the reaction of ketones and ammonia with unsubstituted 1-buten-3-yne.
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Kotlyarevskii, I.L., Vasil'eva, E.D. Pyridine bases derived from 1-buten-3-ynes. Russ Chem Bull 10, 1710–1714 (1961). https://doi.org/10.1007/BF00911446
- Main Product
- Pyridine Base