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Synthesis of n-2-hydroxyethylcrotonamide and n-2-hydroxyethyl-n-methylcrotonamide

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The previously undescribed N-2-hydroxyethylcrotonamide and N-2-hydroxyethyl-N-methylcrotonarnide were synthesized and characterized. N-2-Hydroxyethylcrotonamide was prepared by the reaction of crotonyl chloride and 2-aminoethanol in chloroform. N-2-Hydroxyethyl-N-methylcrotonamide was prepared by the reaction of crotonyl chloride and 2-methylaminoethanol in an aqueous solution of alkali.

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Literature cited

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    S. N. Ushakov, E. M. Lavrent'eva, and K. S. Podgorskaya, Izv. AN SSSR. Otd. khim, n. 1959, 91.

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Ushakov, S.N., Aleev, K.M. Synthesis of n-2-hydroxyethylcrotonamide and n-2-hydroxyethyl-n-methylcrotonamide. Russ Chem Bull 11, 641–642 (1962).

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  • Chloride
  • Aqueous Solution
  • Chloroform
  • Crotonyl
  • Crotonyl Chloride