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Synthesen und reaktionen von pyridazinderivaten, 1. Mitt.: a) Eine neue synthese der pyridazin-4-carbonsäure, b) Darstellung und reaktionen von 3-oxo-3-(4′-pyridazinyl)-propionsäureäthylester

Syntheses and reactions of pyridazine derivatives. 1st comm.: a) A new synthesis of pyridazine-4-carboxylic acid, b) synthesis and reactions of ethyl-3-oxo-3-(4′-pyridazinyl)-propionate

Abstract

Pyridazine-4-carboxylic acid is prepared in high yield by catalytic hydrogenation of 3.6-dichloropyridazine-4-carboxylic acid.Claisen condensation of its ethyl ester with ethyl acetate yields ethyl 3-oxo-3-(4′-pyridazinyl)-propionate (6), the condensation reactions of which with urea, thiourea, phenylhydrazine and hydroxylamine are described. 4-Acetylpyridazine is prepared from6.

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Herrn Prof. Dr.K. Jentzsch mit besten Wünschen zum 60. Geburtstag gewidmet.

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Heinisch, G. Synthesen und reaktionen von pyridazinderivaten, 1. Mitt.: a) Eine neue synthese der pyridazin-4-carbonsäure, b) Darstellung und reaktionen von 3-oxo-3-(4′-pyridazinyl)-propionsäureäthylester. Monatshefte für Chemie 104, 953–962 (1973). https://doi.org/10.1007/BF00903909

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