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The effect of cyanide and azide on the mutagenic activity of the pyrrolizidine alkaloid heliotrine inDrosophila melanogaster

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Summary

Neither cyanide nor azide were found to increase the spontaneous sex-linked lethal frequency or the chromosome breakage frequency inDrosophila. However, both inhibitors produced a slight increase in the heliotrine induced sex-linked lethal and chromosome breakage frequencies in all broods except for the possible exception of the first, the increase for the combined brood totals being statistically significant. Possible mechanisms underlying the enhancing effects of both cyanide and azide are discussed.

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Brink, N.G. The effect of cyanide and azide on the mutagenic activity of the pyrrolizidine alkaloid heliotrine inDrosophila melanogaster . Zeitschrift für Vererbungslehre 94, 331–335 (1963). https://doi.org/10.1007/BF00897592

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Keywords

  • Cyanide
  • Alkaloid
  • Azide
  • Enhance Effect
  • Mutagenic Activity