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The effect of cyanide and azide on the mutagenic activity of the pyrrolizidine alkaloid heliotrine inDrosophila melanogaster

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Neither cyanide nor azide were found to increase the spontaneous sex-linked lethal frequency or the chromosome breakage frequency inDrosophila. However, both inhibitors produced a slight increase in the heliotrine induced sex-linked lethal and chromosome breakage frequencies in all broods except for the possible exception of the first, the increase for the combined brood totals being statistically significant. Possible mechanisms underlying the enhancing effects of both cyanide and azide are discussed.

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  1. Auerbach, C.: The study of chemical mutagens by brood pattern analysis and by the scoring of ratios between visible and lethal mutations. Z. indukt. Abstamm.-u. Vererb.-Lehre88, 619 (1957).

  2. Avanzi, S.: Chromosome breakage by pyrrolizidine alkaloids and modification of the effect by cysteine. Caryologia14, 251 (1961).

  3. Clark, A. M.: Mutagenic activity of the alkaloid heliotrine inDrosophila. Nature (Lond.)183, 731 (1959).

  4. Culvenor, C. C., A. T. Dann andA. T. Dick: Alkylation as the mechanism by which the hepatotoxic pyrrolizidine alkaloids act on cell nuclei. Nature (Lond.)195, 570 (1962).

  5. Kihlman, B. A.: Oxygen and the production of chromosome aberrations by chemicals and X-rays. Hereditas (Lund.)41, 384 (1955).

  6. —: Biochemical aspects of chromosome breakage. Advant. Genet.10, 1 (1961).

  7. Read, J.: Radiation biology ofVicia faba in relation to the general problem, p. 174. Oxford: Blackwell Scientific Publications 1959.

  8. Schneiderman, H. A., M. Ketchel andC. M. Williams: The physiology of insect diapause. VI. Effects of temperature, oxygen tension, and metabolic inhibitors onin vitro spermatogenesis in theCecropia silkworm. Biol. Bull.105, 188 (1953).

  9. Sobels, F. H.: The influence of catalase inhibitors on the rate of X-ray induced mutations inDrosophila melanogaster. Proc. 1st. int. Photobiol. Congr. Amsterdam 1954, p. 332.

  10. Sobels, F. H.: Dose rate, cyanide and some other factors influencing repair of mutational damage inDrosophila. Abh. dtsch. Akad. Wiss. Berl. Nr 1. Kl. Med., 115 (1962).

  11. Swanson, G. P., andT. Merz: Factors influencing the effect of β-propiolactone on chromosomes ofVicia faba. Science129, 1364 (1959).

  12. Wolff, S., andH. E. Luippold: Metabolism and chromosome break rejoining. Science122, 231 (1955).

  13. Yanders, A. F.: Relative time of eclosion ofDrosophila females heterozygous for sex-linked recessive lethals. Amer. Naturalist92, 189 (1958).

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Brink, N.G. The effect of cyanide and azide on the mutagenic activity of the pyrrolizidine alkaloid heliotrine inDrosophila melanogaster . Zeitschrift für Vererbungslehre 94, 331–335 (1963). https://doi.org/10.1007/BF00897592

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  • Cyanide
  • Alkaloid
  • Azide
  • Enhance Effect
  • Mutagenic Activity