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Phase II trial of trimetrexate in untreated advanced gastric carcinoma

A Southwest Oncology Group study

Summary

Twenty-three evaluable patients with advanced gastric adenocarcinoma were treated with trimetrexate at doses of 8–12 mg/m2 intravenously daily for five days, with cycles repeated every 21 days. One complete response was seen for an overall response rate of 4% (95% confidence interval 0–22%). Hematologie toxicities of grade ≥ 3 were seen in 10/23 patients, and overall any grade 3 or greater toxicity was seen in 14/ 23 patients. Trimetrexate has minimal activity against gastric adenocarcinoma in this study, and no further investigation of this agent at this dose and schedule is recommended in this disease.

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References

  1. 1.

    Boring CC, Squires TS, Tong T, Montgomery S: Cancer statistics, 1994. Ca 44:7–26, 1994

  2. 2.

    Panettiere FJ, Haas C, McDonald B, Costanzi JJ, Talley RW, Athens J, Oishi N, Heilbrun LK, Chen TT: Drug combinations in the treatment of gastric adenocarcinoma. A randomized Southwest Oncology Group study. J Clin Oncol 2:420–424, 1984

  3. 3.

    Bertino JR, Sawicki WL, Moroson BA, Cashmore AR, Elslager EL: 2,4-Diamno-5-methyl-,(3,4,5-trimethoxyanilino) methyl, quinazoline (TMQ), a potent nonclassical folate antagonist inhibitor. I. Effect on dihydrofolate reductase and growth of rodent tumorsin vitro andin vivo. Biochem Pharmacol 28:1983–1987, 1979

  4. 4.

    Kamen BA, Eibl B, Cashmore A, Bertino J: Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)-methyl]quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cellsin vitro. Biochem Pharmacol 33:1697–1699, 1984

  5. 5.

    Diddens H, Neithammer D, Jackson RC: Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate. Cancer Res 50:3284–3288, 1990

  6. 6.

    Clinical Brochure on Trimetrexate Glucuronate (TMTX), NSC 352122. Bethesda, MD: Division of Cancer Treatment, National Cancer Institute, 1983

  7. 7.

    Green S, Weiss G: Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria. Inv New Drugs 10:239–253, 1992

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Author information

Correspondence to Catherine M. Tangen.

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Hantel, A., Tangen, C.M., Macdonald, J.S. et al. Phase II trial of trimetrexate in untreated advanced gastric carcinoma. Invest New Drugs 12, 155–157 (1994). https://doi.org/10.1007/BF00874448

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Key words

  • trimetrexate
  • gastric adenocarcinoma