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Proton magnetic resonance spectroscopy and intracranial tumours: Clinical perspectives


Proton magnetic resonance spectroscopy (1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absentN-acetylaspartate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neoplasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of1HMRS and future applications are reviewed.

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Correspondence to Andrea Falini.

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Falini, A., Calabrese, G., Origgi, D. et al. Proton magnetic resonance spectroscopy and intracranial tumours: Clinical perspectives. J Neurol 243, 706–714 (1996). https://doi.org/10.1007/BF00873976

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Key words

  • Brain metabolism Brain tumours

Magnetic resonance spectroscopy

  • Brain metabolism Brain tumours