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Phase II clinical study of pirarubicin in hormone resistant prostate cancer

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Twenty one patients with hormone resistant prostate cancer were entered in a phase II study of pirarubicin 70 mg/m2, as a single intravenous injection given at 21 day intervals. All patients had leukopenia (9 severe or life threatening) and 2 died of septicemia. Thrombocytopenia occurred in 5 patients (one life threatening) and anemia in 12 patients. One partial response of 3 months duration was documented. Pirarubicin 70 mg/m2 given intravenously at 21 day intervals causes severe hematological toxicity and has minimal therapeutic activity in patients with hormone resistant prostate cancer.

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Author information

Correspondence to Bernardo Leon Rapoport or Geoffrey Falkson.

Additional information

Pirarubicin was supplied by: Behringwerke AG, Marberg, Germany.

Supported in part by a grant from the National Cancer Association of South Africa.

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Rapoport, B.L., Falkson, G. Phase II clinical study of pirarubicin in hormone resistant prostate cancer. Invest New Drugs 10, 119–121 (1992). https://doi.org/10.1007/BF00873129

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Key words

  • pirarubicin
  • hormone resistant prostate cancer