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DNA vaccines: safety and efficacy issues

Summary

DNA technology has been harnessed to produce a variety of plasmid-based vaccines designed to prevent viral, bacterial and parasitic infections. The rapid adoption and implementation of this novel vaccine strategy carries with it important safety and efficacy concerns. This review will focus on whether DNA vaccines (1) are likely to induce systemic or organ-specific autoimmune disease, (2) have the potential to induce tolerance rather than immunity, and (3) are as effective in individuals with depressed immune function as they are in healthy adults.

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Correspondence to Dennis M. Klinman.

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Klinman, D.M., Takeno, M., Ichino, M. et al. DNA vaccines: safety and efficacy issues. Springer Semin Immunopathol 19, 245–256 (1997). https://doi.org/10.1007/BF00870272

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Keywords

  • Internal Medicine
  • Autoimmune Disease
  • Immune Function
  • Healthy Adult
  • Harness