Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Enzymic and nonenzymic systems protecting photoreceptor membranes against active forms of oxygen and lipid peroxides

  • 14 Accesses

  • 3 Citations


Activity of the enzyme systems protecting membrane structures of photoreceptor cells Ithe outer and inner segments of the retinal rods) against active forms of oxygen (superoxide dismutase) and lipid peroxide (glutathione peroxidase, glutathione reductase) was shown to be low. At the same time a high concentration of α-tocopherol (vitamin E) was demonstrated in these membranes. It is concluded that the polyene lipids of the retinal photoreceptors are protected against the harmful action of lipid peroxidation by the vitamin E system.

This is a preview of subscription content, log in to check access.

Literature Cited

  1. 1.

    Yu. A. Vladimirov and A. I. Archakov, Peroxidation of Lipids in Biological Membranes [in Russian], Moscow (1972).

  2. 2.

    C. S. Foote, in: Free Radicals in Biology, Vol. 2, New York (1976), pp. 85–133.

  3. 3.

    L. V. Belousova, L. B. Bratkovskaya, I. V. Galushchenko, et al., Biokhimiya, No. 10, 1800 (1977).

  4. 4.

    V. E. Kagan, A. A. Shvedova, et al., Biofizika No. 6, 1043 (1975).

  5. 5.

    V. E. Kagan, G. V. Barybina, and K. N. Novikov, Byull. Éksp. Biol. Med., No. 4, 411 (1977).

  6. 6.

    M. V. Zueva, A. A. Shvedova, and O. I. Shcherbatova, Vestn. Oftal'mol., No. 3 56 (1977).

  7. 7.

    E. Kimura, Jpn. J. Physiol.,3, 25 (1952).

  8. 8.

    D. S. Papermaster and W. V. Dreyer, Biochemistry (Washington),13, 2438 (1971).

  9. 9.

    I. Fridovich, Account. Chem. Res.,5, 321 (1972).

  10. 10.

    V. Z. Lankin and S. M. Gurevich, Dokl. Akad. Nauk SSSR,226, 705 (1975).

  11. 11.

    S. L. Taylor and M. P. Lamden, Lipids,11, 530 (1976).

  12. 12.

    M. O. Hall and D. O. Hall, Biochem. Biophys. Res. Commun.,67, 1199 (1975).

  13. 13.

    E. W. Abrahamson, R. S. Fager, and W. T. Mason, Exp. Eye Res.,18, 51 (1974).

  14. 14.

    R. Fried and P. Mandel, J. Neurochem.,24, 433 (1975).

  15. 15.

    C. C. Farnsworth and E. A. Dratz, Biochim. Biophys. Acta,443, 556 (1976).

Download references

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kagan, V.E., Lankin, V.Z., Shvedova, A.A. et al. Enzymic and nonenzymic systems protecting photoreceptor membranes against active forms of oxygen and lipid peroxides. Bull Exp Biol Med 88, 856–858 (1979).

Download citation

Key Words

  • superoxide dismutase
  • glutathione peroxidase
  • glutathione reductase
  • α-tocopherol
  • membranes of photoreceptors