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Inhibition of corticosteroid production by pineal factor

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The effect of a factor isolated from the bovine pineal gland on the blood corticosteroid level and on the ability of isolated adrenal tissue to synthesize these compounds was investigated in experiments on male Wistar rats. The method of obtaining the pineal fraction is described. Its injection in a dose of 2 mg/100 g body weight lowered the blood corticosteroid level by 74, 69, 40, 64, and 63% after 4, 5, 7, 9, and 12 days respectively. The ability of the adrenal tissue to synthesize corticosteroids was depressed. The results are evidence that the pineal gland participates in the regulation of adrenal function.

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Institute of Endocrinology and Metabolism, Kiev. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 8, pp. 146–147, August, 1979.

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Komissarenko, V.P., Tron'ko, N.D., Zryakov, O.N. et al. Inhibition of corticosteroid production by pineal factor. Bull Exp Biol Med 88, 834–836 (1979). https://doi.org/10.1007/BF00869207

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Key Words

  • adrenal glands
  • steroid production
  • pineal factor