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Hypothyroidism in infants with nephrotic syndrome


Thyroid function indices were studied in five children with nephrotic syndrome in the 1st year of life. Four had primary hypothyroidism as defined by low serum free tri-iodothyronine (FT3) and free thyroxine (FT4), and high serum thyroid-stimulating hormone (TSH) levels. One patient with low serum FT3 and FT4 had a normal TSH level. T4 replacement therapy lowered TSH to normal levels in all four patients and normalized FT4 in three of them. There were no significant changes in serum FT3 levels. Adrenal function was studied in three patients, none had adrenal calcification or hypoadrenocorticism. This study supports the existence of a hypothyroid state in some infants with nephrotic syndrome. Routine thyroid screening and early replacement therapy is recommended.

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  1. 1.

    McLean RH, Kennedy TL, Rosoulpour M, Ratzan SK, Siegel NJ, Kauschansky A, Genel M (1982) Hypothyroidism in the congenital nephrotic syndrome. J Pediatr 101: 72–75

  2. 2.

    DeLuca FD, Gernelli M, Pandullo EM, Barberio G, Benvenga S, Trimarchi F (1983) Changes in thyroid function tests in infantile nephrotic syndrome. Horm Metab Res 15: 258–259

  3. 3.

    Wilschanski M, Hirsch HJ, Algur N, Drukker A (1992) Abnormal thyroid function in the congenital nephrotic syndrome. Pediatr Nephrol 6: C134

  4. 4.

    Afrasiabi MA, Vaziri ND, Gwinup G, Mays DM, Barton CH, Ness NL, Valenta LJ (1979) Thyroid function studies in the nephrotic syndrome. Ann Intern Med 90: 335–338

  5. 5.

    Gavin LA, McMohan FA, Castle JN, Cavalieri RR (1978) Alterations in serum thyroid hormones and thyroxine-binding globulin in patients with nephrosis. J Clin Endocrinol Metab 46: 125–130

  6. 6.

    Feinstein EL, Kaptein EM, Nicoloff JT, Massry SG (1982) Thyroid function in patients with nephrotic syndrome and normal renal function. Am J Nephrol 2: 70–76

  7. 7.

    Robbins J, Rall JE, Peterson ML (1957) Thyroxine binding by serum and urine proteins in nephrosis, qualitative aspects. J Clin Invest 36: 1333–1342

  8. 8.

    Fonseca V, Thomas M, Katrak A, Sweny P, Moorhead JF (1991) Can urinary thyroid loss cause hypothyroidism. Lancet 338: 475–478

  9. 9.

    Mattoo TK, Al-Sowailem AM, Al-Harbi MS, Mahmood MA, Katawee Y, Hassab MH (1992) Nephrotic syndrome in 1 st year of life and the role of unilateral nephrectomy. Pediatr Nephrol 6: 16–18

  10. 10.

    Warady BA, Howard CP, Hellerstein S, Alon U, Grunt JA (1993) Congenital nephrosis in association with hypothyroidism and hypoadrenocorticism. Pediatr Nephrol 7: 79–80

  11. 11.

    Powers RJ, Cohen ML, Williams J (1990) Adrenal calcification in congenital nephrotic syndrome in three American Indians. Pediatr Nephrol 4: 29–31

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Mattoo, T.K. Hypothyroidism in infants with nephrotic syndrome. Pediatr Nephrol 8, 657–659 (1994).

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Key words

  • Nephrotic syndrome
  • Hypothyroidism