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Stimulation of growth hormone secretion in children with X-linked hypophosphatemia

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X-linked hypophosphatemia is characterized by low serum phosphorus, relative vitamin D deficiency and rickets. Despite adequate metabolic control with oral phosphate and vitamin D therapy, patients with X-linked hypophosphatemia have short stature. Whether growth hormone (GH) deficiency plays a role in short stature in patients with X-linked hypophosphatemia is not known. The purpose of this report was to investigate the response of GH to sequential paired pharmacological stimulation in patients with X-linked hypophosphatemia. Basal GH was 3.8±0.7 ng/ml, insulin-like growth factor-I (IGF-I) was 225±38 ng/ml and IGF binding protein-3 was 3.0±0.2 mg/l in 16 children studied with X-linked hypophosphatemia. In response tol-dopa and arginine hydrochloride stimulation, serum GH rose to above 7 mg/ml in all patients. Thus, the short stature in patients with X-linked hypophosphatemia is not due to a GH/IGF-I secretory defect.

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Correspondence to Mouin G. Seikaly.

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Seikaly, M.G., Baum, M. Stimulation of growth hormone secretion in children with X-linked hypophosphatemia. Pediatr Nephrol 9, 751–752 (1995). https://doi.org/10.1007/BF00868733

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Key words

  • X-linked hypophosphatemia
  • Growth hormone
  • Insulin-like growth factor-I
  • Insulin-like growth factor, binding protein-3