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Early MRI findings in Creutzfeldt-Jakob disease


We describe the MRI changes preceding the onset of myoclonus in two patients whose post-mortem examination confirmed the diagnosis of Creutzfeldt-Jakob disease (CJD). MRI showed changes in the striatum early in the course of CJD (2–6 months after the onset of apathy, interpreted as depression, and 1–2 months before the onset of further clinical symptoms). Only in one patient did electroencephalography record the typical triphasic sharp-waves, 1 month after MRI.

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Correspondence to Marco Onofrj.

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Onofrj, M., Fulgente, T., Gambi, D. et al. Early MRI findings in Creutzfeldt-Jakob disease. J Neurol 240, 423–426 (1993). https://doi.org/10.1007/BF00867355

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Key words

  • Creutzfeldt-Jacob disease
  • Magnetic resonance imaging
  • Computed tomography
  • Electroencephalography