Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Streptococcus pneumoniae-induced hemolytic uremic syndrome: a case for early diagnosis

  • 53 Accesses

  • 42 Citations

Abstract

Hemolytic uremic syndrome associated with infection by neuraminidase-producingStreptococcus pneumoniae usually presents with fulminant pneumonia and has a high mortality rate. Post-pneumococcal hemolytic uremic syndrome may occur earlier in life than classical hemolytic uremic syndrome. We describe an 18-month-old male with hemolytic uremic syndrome,S. pneumoniae pneumonia, and T-antigen activation characteristic of neuraminidase activity. We have summarized the features of this case and 11 previously reported children. As the use of blood products containing IgM may aggravate this disorder, early recognition of hemolytic uremic syndrome associated withS. pneumoniae neuraminidase production may lead to improved patient outcome through the judicious use of blood products.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Fischer K, Poschmann A, Oster H (1971) Hamolyse bei schwerer Pneumonie infolge Neuraminidasewirkung. Monatsschr Kinderheilk 119:2

  2. 2.

    Kim YD, Prakash U, Weber GF, Hargie M (1979) Nature of human serum blood group T antibodies. Immunol Commun 8: 397–406

  3. 3.

    Novak RW, Martin CR (1983) Hemolytic-uremic syndrome and T-cryptantigen exposure by neuraminidase-producing pneumococci: an emerging problem? Pediatr Pathol 1: 409–413

  4. 4.

    Feld LG, Springate JE, Darragh R, Fildes RD (1987) Pneumococcal pneumonia and hemolytic uremic syndrome. Pediatr Infect Dis J 6: 693–695

  5. 5.

    Klein PJ, Bulla M, Newman RA, Müller P, Uhlenbruck G, Schaefer HE, Krüger G, Fisher R (1977) Thomsen-Freidenreich antigen in haemolytic-uraemic syndrome. Lancet II: 1024–1025

  6. 6.

    Martinot A, Hue V, Leclerc F, Chenaud M (1989) Haemolytic-uraemic syndrome associated withStreptococcus pneumoniae meningitis. Eur J Pediatr 148: 648–649

  7. 7.

    Alon U, Adler SP, Chan JCM (1984) Hemolytic-uremic syndrome associated withStreptococcus pneumoniae: report of a case and review of the literature. Am J Dis Child 138: 496–499

  8. 8.

    Seger R, Joller P, Baerlocher K, Kenny A, Dulake C, Leumann E, Spierig M, Hitzig WH (1980) Hemolytic-uremic syndrome associated with neuraminidase-producing microorganisms: treatment by exchange transfusion. Helv Paediatr Acta 35: 359–367

  9. 9.

    McGraw ME, Lendon M, Stevens RF, Postlethwaite RJ, Taylor CM (1989) Haemolytic uraemic syndrome and the Thomsen Friedenreich antigen. Pediatr Nephrol 3: 135–139

  10. 10.

    Austrian R, Gold J (1964) Pneumococcal bacteremia with especial reference to bacteremic pneumococcal pneumonia. Ann Intern Med 60: 759–776

  11. 11.

    Seges RA, Kenny W, Bird GWG (1981) Pediatric surgical patients with severe anaerobic infections: report of 16 T-antigen positive cases and possible hazards of blood transfusions. J Pediatr Surg 16: 905–910

  12. 12.

    Levene C, Levene NA, Duskila D, Manny N (1988) Red cell polyagglutination. Transfus Med Rev 2: 176–185

Download references

Author information

Correspondence to Lars C. Erickson.

Additional information

The views expressed in this manuscript are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defeuse, or the United States Government.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Erickson, L.C., Smith, W.S., Biswas, A.K. et al. Streptococcus pneumoniae-induced hemolytic uremic syndrome: a case for early diagnosis. Pediatr Nephrol 8, 211–213 (1994). https://doi.org/10.1007/BF00865481

Download citation

Key words

  • Hemolytic uremic syndrome
  • Streptococcus pneumoniae
  • Pneumonia