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Pediatric Nephrology

, Volume 10, Issue 1, pp 108–112 | Cite as

The renin-angiotensin system in transgenic rats

  • Jürgen Wagner
  • Felix Thiele
  • Detlev Ganten
Invited Review

Abstract

Transgenic animals are used to study the function, regulation and in vivo expression of genes. The effects of the genes of the renin-angiotension system on blood pressure regulation and hypertension were investigated in transgenic rats. The role of the renin-angiotensin system in the development of cardiovascular hypertrophy of hypertensive renal damage was analysed, as well as its interaction with other hormonal systems, i.e. adrenal steroids. The development of a transgenic rat strain carrying the mouse REN-2 gene has provided a new model of hypertension with systolic blood pressure values of 200 mmHg. This model is characterised by low active plasma renin, hyperproreninaemia and high expression of renin in the adrenal gland and other extrarenal tissues. Transgenic rats with thehuman components of the renin-angiotensin system expressed the human renin and angiotensinogen proteins which interacted species-specifically in transgenic rats. These transgenic models demonstrate the feasibility of studying the function of candidate hypertension genes in transgenic animals. In the future, further refinements in transgene construction, mutation, and modification can be tested in such transgenic animal models.

Key words

Transgenic rat Transgene Renin Angiotensinogen Cardiovascular system Pharmacology 

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Copyright information

© IPNA 1996

Authors and Affiliations

  • Jürgen Wagner
    • 1
  • Felix Thiele
    • 1
  • Detlev Ganten
    • 1
  1. 1.Max Delbrück Centrum for Molecular MedicineBerlinGermany

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