The bromine atom is replaced by a nucleophile in the reaction ofα-bromo-4-hydroxy-3,5-di-tert-butyl-acetophenone with alkaline agents, and the corresponding 4-hydroxy-3,5-di-tert-butylacetophenone derivatives are formed.
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V. I. Volod'kina, V. V. Ershov, A. A. Volod'kin, and I. S. Belostotskaya, Izv. Akad. Nauk SSSR, Ser. Khim., 2406 (1970).
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 649–651, March, 1972.
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Volod'kin, A.A., Ershov, V.V. & Volod'kina, V.I. Reaction ofα-bromo-4-hydroxy-3,5-di-tert-butylacetophenone with alkaline agents. Russ Chem Bull 21, 613–614 (1972). https://doi.org/10.1007/BF00863226
- Bromine Atom
- Alkaline Agent