Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Multifocal peripheral neuropathy in eosinophilic fasciitis

Summary

Polyneuropathy may complicate eosinophilia associated connective tissue disease. We report a multifocal neuropathy in a patient with eosinophilic fasciitis proven by demonstrating an eosinophilic cellular infiltrate in a fascial biopsy specimen from the forearm. Sural nerve biopsy revealed lymphocytic cuffing of epineural arterioles. Although described in thel-tryptophan-related eosinophilia-myalgia syndrome, peripheral neuropathy with these features has not been previously noted in a patient with eosinophilic fasciitis who had not consumedl-tryptophan.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Barnes L, Rodnan GP, Medsger TA, Short D (1979) Eosinophilic fasciitis. Am J Pathol 96:493–518

  2. 2.

    Belongia EA, Hedberg CW, Gleich GJ, et al (1990) An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use. N Engl J Med 322:357–365

  3. 3.

    Centres for Disease Control (1989) Eosinophilia-myalgia syndrome andl-tryptophan containing products — New Mexico, Minnesota, Oregon and New York. MMWR 38:785–788

  4. 4.

    Doyle JA, Ginsburg WW (1989) Eosinophilic fasciitis. Med Clin North Am 73:1157–1166

  5. 5.

    Freundlich B, Werth VP, Rook AH, et al (1990)l-tryptophan ingestion associated with eosinophilic fasciitis but not progressive systemic sclerosis. Ann Intern Med 112:758–762

  6. 6.

    Herson S, Brechignac S, Piette JC, et al (1990) Capillary microscopy during eosinophilic fasciitis in 15 patients: distinction from systemic scleroderma. Am J Med 88:598–600

  7. 7.

    Jaffe I, Kopelman R, Baird R, et al (1990) Eosinophilic fasciitis associated with the eosinophilia-myalgia syndrome. Am J Med 88:542–546

  8. 8.

    Martin RW, Duffy J, Engle AG, et al (1990) The clinical spectrum of the eosinophilia-myalgia syndrome associated withl-tryptophan ingestion. Ann Intern Med 113:124–134

  9. 9.

    Monaco S, Lucci B, Laperchia N, et al (1988) Polyneuropathy in hypereosinophilic syndrome. Neurology 38:494–496

  10. 10.

    Smith BE, Dyck PJ (1990) Peripheral neuropathy in the eosinophilia-myalgia syndrome associated withl-tryptophan ingestion. Neurology 40:1035–1040

Download references

Author information

Correspondence to Michael Donaghy.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Satsangi, J., Donaghy, M. Multifocal peripheral neuropathy in eosinophilic fasciitis. J Neurol 239, 91–92 (1992). https://doi.org/10.1007/BF00862980

Download citation

Key words

  • Eosinophilic fasciitis
  • Multifocal polyneuropathy