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Iodination of 2-aryl-3-hydroxypyridines


  1. 1.

    The authors have studied iodination of 2-phenyl-, 2-(4'-alkylphenyl)-, 2-(4'-chlorophenyl)-, and 2-(4'-methoxyphenyl)-3-hydroxypyridines.

  2. 2.

    Iodination of 2-aryl-3-hydroxypyridines takes place in the 6 position of theβ-pyridole ring.

  3. 3.

    Introduction of electron-donor substituents into the phenyl ring does not change the direction of iodination of 2-aryl-3-hydroxypyridines.

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Literature cited

  1. 1.

    O. V. Schickh, A. Binz, and A. Schulz, Ber., 69, 2593 (1936).

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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2400–2401, October, 1970.

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Smirnov, L.D., Kuz'min, V.I., Lezina, V.P. et al. Iodination of 2-aryl-3-hydroxypyridines. Russ Chem Bull 19, 2263–2264 (1970).

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  • Phenyl
  • Phenyl Ring
  • Chlorophenyl
  • Methoxyphenyl
  • Hydroxypyridines