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Effect of rifampin onStaphylococcus aureus colonization in children on chronic peritoneal dialysis

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The efficacy of rifampin in eliminatingStaphylococcus aureus colonization was evaluated in a pediatric peritoneal dialysis population. Six children with documented nasal colonization were treated for 7 days with rifampin and cloxacillin. Although antimicrobial therapy eliminated nasal carriage in all patients, recolonization occurred in 66%. Exit site colonization proved difficult to eradicate with negative cultures documented in only 3 of 5 children after rifampin/cloxacillin therapy. AlthoughS. aureus carriage is a risk factor forS. aureus infections, efforts to eradicate carriage with rifampin are hindered by rapid recolonization.

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  1. 1.

    Alexander SR, Sullivan EK, Harmon WE, Stablein DM, Tejani A, for the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) (1993) Maintenance dialysis in North American children and adolescents: a preliminary report. Kidney Int 44 [Suppl 43]:S104-S109

  2. 2.

    Howard RL, Millspaugh J, Teitelbaum I (1990) Adult and pediatric peritonitis rates in a home dialysis program: comparison of continuous ambulatory and continuous cycling peritoneal dialysis. Am J Kidney Dis 16:469–472

  3. 3.

    Piraino B (1990) A review ofStaphylococcus aureus exit site and tunnel infections in peritoneal dialysis patients. Am J Kidney Dis 16:89–95

  4. 4.

    Zimmerman SW, O'Brien M, Wiedenhoeft FA, Johnson CA (1988)Staphylococcus aureus peritoneal catheter-related infections: a cause of catheter loss and peritonitis. Perit Dial Int 8: 191–194

  5. 5.

    Pignatari A, Pfaller M, Hollis R, Sesso R, Leme I, Herwaldt L (1990)Staphylococcus aureus colonization and infection in patients on continuous ambulatory peritoneal dialysis. J Clin Microbiol 28:1898–1902

  6. 6.

    Luzar MA, Coles GA, Faller B, Slingeneyer A, Dah GD, Briat C, Wone C, Knefati Y, Kessler M, Peluso F (1990)Staphylococcus aureus nasal carriage and infection in patients on continuous peritoneal dialysis. N Engl J Med 322:505–509

  7. 7.

    Sesso R, Draire S, Castelo A, Sato I, Leme I, Barbosa D, Ramos O (1989)Staphylococcus aureus skin carriage and development of peritonitis in patients on continuous ambulatory peritoneal dialysis. Clin Nephrol 31:264–268

  8. 8.

    Yu VL, Goetz A, Wagener M, Smith PB, Rihs JD, Hanchett J, Zuravleff JJ (1986)Staphylococcus aureus nasal carriage and infection in patients on hemodialysis: efficacy of antibiotic prophylaxis. N Engl J Med 315:91–96

  9. 9.

    Piraino B, Perlmutter JA, Holley JL, Bernardini J (1993)Staphylococcus aureus peritonitis is associated withStaphylococcus aureus nasal carriage in peritoneal dialysis patients. Perit Dial Int 13 [Suppl 2]:332–334

  10. 10.

    Zimmerman SW, Ahrens E, Johnson CA, Craig W, Leggett J, O'Brien M, Oxton L, Roecker EB, Engeseth S (1991) Randomized controlled trial of prophylactic rifampin for peritoneal dialysisrelated infections. Am J Kidney Dis 18:225–231

  11. 11.

    Wheat LJ, Kohler RB, Luft FC, White A (1983) Long-term studies of the effect of rifampin on nasal carriage of coagulase-positive staphylococci. Rev Infect Dis 5 [Suppl 3]: S459-S462

  12. 12.

    Tuazon CU (1984) Skin and skin structure infections in the patient at risk: carrier state ofStaphylococcus aureus. Am J Med 76: 166–171

  13. 13.

    Davies SJ, Ogg CS, Cameron JS, Poston S, Noble WC (1989)Staphylococcus aureus nasal carriage, exit-site infection and catheter loss in patients treated with continuous ambulatory peritoneal dialysis (CAPD). Perit Dial Int 9:61–64

  14. 14.

    Sande MA, Mandell GL (1975) Effect of rifampin on nasal carriage ofStaphylococcus aureus. Antimicrob Agents Chemother 7: 294–297

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Correspondence to Coral D. Hanevold.

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Hanevold, C.D., Fisher, M.C., Waltz, R. et al. Effect of rifampin onStaphylococcus aureus colonization in children on chronic peritoneal dialysis. Pediatr Nephrol 9, 609–611 (1995). https://doi.org/10.1007/BF00860952

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Key words

  • Staphylococcus aureus
  • Nasal carriage
  • Peritonitis
  • Exit site infection
  • Peritoneal dialysis