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Effect of rifampin onStaphylococcus aureus colonization in children on chronic peritoneal dialysis

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Abstract

The efficacy of rifampin in eliminatingStaphylococcus aureus colonization was evaluated in a pediatric peritoneal dialysis population. Six children with documented nasal colonization were treated for 7 days with rifampin and cloxacillin. Although antimicrobial therapy eliminated nasal carriage in all patients, recolonization occurred in 66%. Exit site colonization proved difficult to eradicate with negative cultures documented in only 3 of 5 children after rifampin/cloxacillin therapy. AlthoughS. aureus carriage is a risk factor forS. aureus infections, efforts to eradicate carriage with rifampin are hindered by rapid recolonization.

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Correspondence to Coral D. Hanevold.

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Hanevold, C.D., Fisher, M.C., Waltz, R. et al. Effect of rifampin onStaphylococcus aureus colonization in children on chronic peritoneal dialysis. Pediatr Nephrol 9, 609–611 (1995). https://doi.org/10.1007/BF00860952

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Key words

  • Staphylococcus aureus
  • Nasal carriage
  • Peritonitis
  • Exit site infection
  • Peritoneal dialysis