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Familial hypomagnesaemia — hypercalciuria leading to end-stage renal failure

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Several disorders of hypomagnesaemia of hetary renal origin are now recognised. The cases of two sisters from a consanguineous marriage with the syndrome of renal magnesium wasting, hypercalciuria and nephrocalcinosis are presented. Pathological examination of the heterozygous parental kidneys revealed mild focal interstitial fibrosis. This condition is a previously unreported cause of end-stage renal failure in chilhhood, and this report suggests that transplantation from heterozygous parental donors can be successfully undertaken without recurrence currence of the syndrome.

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  1. 1.

    Rodriguez-Soriano J, Vallo A, Garcia-Feuntes M (1987) Hypomagnesaemia of hereditary renal origin. Pediatr Nephrol 1: 465–472

  2. 2.

    Manz F, Scharer K, Janka P, Lombeck J (1978) Renal magnesium wasting, incomplete tubular acidosis, hypercalciuria and nephrocalcinosis in siblings. Eur J Pediatr 128: 67–79

  3. 3.

    Michelis MF, Drash AL, Linarelli LG, De Rubertis FR, Davis BB (1972) Decreased bicarbonate threshold and renal magnesium wasting in a sibship with distal renal tubular acidosis (valuation of the pathophysiologic role of parathyroid hormone). Metabolism 21: 905–920

  4. 4.

    Runeberg L, Collan Y, Josuhen E, Lähdevirta J, Aro A (1975) Hypomagnesemia due to renal disease of unknown etiology. Am J Med 59: 873–881

  5. 5.

    Evans RA, Carter JN, George CRP, Walls RS, Newland RC, McDonald GD, Lawrence JR (1981) The congenital “magnesiumlosing kidney’. Report of two patients. Q J Med 50: 39–52

  6. 6.

    Chao SM, Jones CL, Powell HR, Johnstone L, Francis DMA, Becker GJ, Walker RG (1994) Triple immunosuppression with subsequent prednisolone withdrawal: six years experience in paediatric renal allograft recipients. Pediatr Nephrol 8: 62–69

  7. 7.

    Zelikovic I, Dabbagh S, Friedman A, Goezler M, Chesney R (1987) Severe renal osteodystrophy without elevated immunoreactive parathyroid hormone concentrations in hypomagnesemia due to renal magnesium wasting. Pediatrics 79: 403–409

  8. 8.

    Leumann E, Hoppe B, Neuhaus T (1993) Management of primary oxaluria: efficacy of oral citrate administration. Pediatr Nephrol 7: 207–210

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Correspondence to Harley R. Powell.

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Nicholson, J.C., Jones, C.L., Powell, H.R. et al. Familial hypomagnesaemia — hypercalciuria leading to end-stage renal failure. Pediatr Nephrol 9, 74–76 (1995). https://doi.org/10.1007/BF00858976

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Key words

  • Hypomagnesaemia
  • Hypercalciuria
  • Nephrocalcinosis
  • End-stage renal failure
  • Renal transplantation