We describe a patient with steroid-resistant focal segmental glomerulosclerosis (FSGS) whose serum interleukin-2 (IL-2) levels were markedly elevated in association with disease activity. With cyclosporin A (CsA) treatment, the patient entered remission and serum IL-2 fell to undetectable levels. After cessation of CsA, the patient relapsed and the serum IL-2 levels were elevated again. Reinstitution of CsA therapy was followed by a partial remission and disappearance of detectable serum IL-2 levels.
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Jordan, S.C., Querfeld, U., Toyoda, M. et al. Serum interleukin-2 levels in a patient with focal segmental glomerulosclerosis. Pediatr Nephrol 4, 166–168 (1990). https://doi.org/10.1007/BF00858831
- Focal segmental glomerulosclerosis
- Cyclosporin A