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Hypocomplementaemia and membranoproliferative glomerulonephritis in school urinary screening in Japan

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Yearly screening was performed from 1980 to 1985 in 92,934 school children in the first to ninth grades; a total of 370,148 urine specimens were evaluated. In 1980 and 1981, urinary abnormalities were detected in 0.23% of children examined; the detection rates at the third level of screening for proteinuria, haematuria and haematuria with proteinuria were 0.03%, 0.15% and 0.06%, respectively. The criteria for haematuria were changed from 6 to 20 red blood cells/high power field in the second screening after 1981. Between 1982 and 1985, the equivalent rates were 0.02%, 0.07% and 0.03%, respectively, and the total abnormality prevalence was 0.13%. In 19 children the serum C3 level was below 53 mg/dl; in 5 of these it was below 30 mg/dl. Of these 5 children, 4 underwent renal biopsy and were diagnosed as having membranoproliferative glomerulonephritis.

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  1. 1.

    Kitagawa T (1985) Screening for asymptomatic hematuria and proteinuria in school children — relationship between clinical and laboratory findings and glomerular pathology or prognosis. Acta Paediatr Jpn 27: 366–7373

  2. 2.

    Kitagawa T (1989) Lessons learned from the Japanese nephritic screening study. Pediatr Nephrol 2: 256–263

  3. 3.

    Hisano S, Ueda K (1989) Asymptomatic hematuria and proteinuria: renal pathology and clinical outcome in 54 children. Pediatr Nephrol 3: 229–234

  4. 4.

    West CD (1976) Asymptomatic hematuria and proteinuria in children: causes and appropriate diagnostic studies. J Pediatr 89: 173–182

  5. 5.

    Murakami M, Yamamoto H, Ueda Y (1986) Problems in school urinary screening (in Japanese). Shoninaika 19: 925–930

  6. 6.

    Sakai T (1986) Urinary screening in district. In: Murakami K, Sakai O (eds) Mass urinary screening (in Japanese). Itensha, Tokyo, pp 181–194

  7. 7.

    Kumamoto City (1985) Urinary screening for children (special version for tenth aniversary of school urinalysis) (in Japanese). Kumamoto City, Ishikai, pp 14–42

  8. 8.

    Dodge WF, West EF, Smith EH, Bunce H III (1976) Proteinuria and hematuria in school children. Epidemiology and early natural history. J Pediatr 88: 327–347

  9. 9.

    Murakami M, Yamamoto H, Ueda Y, Murakami K, Yamauchi K (1991) Urinary screening of elementary and junior high-school children over a 13-year period in Tokyo. Pediatr Nephrol 5: 50–53

  10. 10.

    Vehaskari V, Rapola J (1982) Isolated proteinuria: analysis of a school-age population. J Pediatr 101: 661–668

  11. 11.

    Mandelenakin N, Mendoza N, Pirani CL, Pollak VE (1971) Lobular glomerulonephritis and membranoproliferative glomerulonephritis: a clinical and pathological study based on renal biopsies. Medicine (Baltimore) 50: 319–355

  12. 12.

    West CD, McAdams AJ (1987) Membranoproliferative glomerulonephritis. In: Holliday M, Vernier W, Barratt E (eds) Pediatric nephrology, 2nd edn. Williams and Wilkins, Baltimore, pp 420–431

  13. 13.

    Simon P, Ramee MP, Ang KS (1987) Variations of primary glomerulonephritis incidence in a rural area of 400,000 inhabitants in the last decade. Nephron 45: 171

  14. 14.

    Gonzalo A, Matesanz R, Ternal JL (1986) Incidence of membranoproliferative glomerulonephritis in a Spanish population. Clin Nephrol 26: 161

  15. 15.

    Study Group of the Spanish Society of Nephrology (1990) Decreasing incidence of membranoproliferative glomerulonephritis in Spanish children. Pediatr Nephrol 4: 266–267

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Iitaka, K., Igarashi, S. & Sakai, T. Hypocomplementaemia and membranoproliferative glomerulonephritis in school urinary screening in Japan. Pediatr Nephrol 8, 420–422 (1994). https://doi.org/10.1007/BF00856519

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Key words

  • School urinary screening
  • Proteinuria
  • Haematuria
  • Hypocomplementaemia
  • Membranoproliferative glomerulonephritis