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Haemolytic uraemic syndrome and the Thomsen Friedenreich antigen

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Abstract

In three children with haemolytic uraemic syndrome (HUS), evidence of red cell polyagglutinability due to Thomsen Friedenreich antigen (T-antigen) exposure was demonstrated. This was suspected after difficulties in ABO typing and was confirmed using specific antisera. Further supportive evidence included elevation of plasma sialic acid, alteration in red cell surface charge and evidence of T-antigen exposure in the renal biopsy specimen of one patient. Although involvement of this antigen in the pathogenesis of HUS has been associated with a high mortality, all three children have made a complete recovery. With early recognition and subsequent avoidance of plasma products, prognosis of this condition may be improved.

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References

  1. 1.

    Remuzzi G, Misiani R, Marchesi D, Livio M, Mecca G, Gaetano G de, Donati MB (1978) Haemolytic uraemic syndrome: a deficiency of plasma factor(s). Lancet II 2:871–872

  2. 2.

    Misiani R, Appiani AC, Edeforti A, Gotti E, Bettinelli A, Giani M, Rossi E, Remuzzi G, Mecca G (1982) Haemolytic uraemic syndrome: a therapeutic effect of plasma infusion. Br Med J 285:1304–1306

  3. 3.

    Bukowski RM, King JW, Hewlett JS (1977) Plasmapheresis in the treatment of thrombotic thrombocytopaenic purpura. Blood 50:421–427

  4. 4.

    Levin M, Barratt TM (1984) Haemolytic uraemic syndrome. Arch Dis Child 59:397–400

  5. 5.

    Fischer K, Poschmann A, Oster H (1971) Haemolyse bei schwere Pneumonie infolge Neuraminidasewirkung: Immunofluoresenzdarstellung der Cryptantigene. Monatsschr Kinderheilkd 119:2–8

  6. 6.

    Bird GWG (1964) Anti-T in peanuts. Vox Sang 9:748–790

  7. 7.

    Levin M, Holland PC, Nokes TJC, Novelli V, Mola M, Levinsky RJ, Dillon MJ, Barratt TM, Marshall WC (1985) Platelet immune complex interaction in the pathogenesis of Kawasaki disease and childhood polyarteritis. Br Med J 290:1456–1460

  8. 8.

    Levin M, Smith C, Walters SM, Gasgoine P, Barratt TM (1985) Steroid responsive nephrotic syndrome; a generalised disorder of membrane negative charge. Lancet II:239–242

  9. 9.

    Skoza L, Mohes S (1976) Stable thiobarbituric acid chromophore with dimethyl sulphoxide. Application to sialic acid assay in analytical de-o-acetylation. Biochem J 159:703–708

  10. 10.

    Aymard-Henry M, Coleman MT, Dowdle WR, Laver WG, Shild GC, Webster RG (1973) Influenza virus neuraminidase and neuraminidase test proceedures. Bull WHO 48:199–202

  11. 11.

    Levin M, Elkan KB, Nokes TJC, Buckle AM Dillon MJ, Hardisty RM, Barratt TM (1983) Inhibitor of prostacyclin in sporadic haemolytic uraemic syndrome. Arch Dis Child 58:703–708

  12. 12.

    Novak RW, Martin CR, Orsini EN (1983) Haemolytic uraemic syndrome and T-cryptantigen exposure by neuraminidase producing pneumococci: an emerging problem? Pediatr Pathol 1:409–413

  13. 13.

    Klein PJ, Bulla M, Newman RA, Muller P, Uhlenbruck G, Schaeffer HE, Kruger G, Fischer R (1977) Thomsen Friedenreich antigen in haemolytic uraemic syndrome. Lancet II:1024–1025

  14. 14.

    Moorthy B, Makker SP (1979) Haemolytic uraemic syndrome associated with pneumococcal sepsis. J Pediatr 95:558–559

  15. 15.

    Yahev J, Aladjem M, Boichis H, Barzilay Z (1980) Haemolytic uraemic syndrome due to pneumococcal sepsis. Int J Pediatr Nephrol 1:197–198

  16. 16.

    Seger R, Joller P, Bearlocher K, Kenny A, Dulake C, Leumann E, Spierig M, Hitzig WH (1980) Haemolytic uraemic syndrome associated with neuraminidase producing micro-organisms: treatment by exchange transfusion. Helv Paediatr Acta 35:359–367

  17. 17.

    Lehnert U, Maak B, Zintl F (1973) Beitrag zum Krankheitsbild des hämolytisch-urämischen Syndroms. Folia Haematol 99:S 38–39

  18. 18.

    Alon U, Adler SP, Chan JCM (1983) Haemolytic uraemic syndrome associated withStreptococcus pneumoniae. Am J Dis Child 138:496–499

  19. 19.

    Loirat C, Pillion G, Sansino E, Guesnu M, Mathieu H (1983) Secondary haemolytic and uraemic syndromes (HUS) in children. Eur J Pediatr 140:199

  20. 20.

    Eyben FE von, Szpirt W (1985) Pneumococcal sepsis with haemolytic uraemic syndrome in the adult. Nephron 40:501–502

  21. 21.

    Seges RA, Kenny A, Bird GWG, Wingham H, Baals H, Stauffer UG (1981) Paediatric surgical patients with severe anaerobic infection: report of 16 T-antigen positive cases and possible hazards of blood transfusion. J Pediatr Surg 16:905–910

  22. 22.

    Seger R, Joller P, Kenny A, Hitzig W, Metaxas M, Metaxas-Buhler M (1979) Potential hazards of blood transfusion in clostridia associated necrotising enterocolitis. Lancet I:48–49

  23. 23.

    Mullard GW, Thomsen IH, Lee D, Owen WG (1981) Strong T transformation associated with a severe haemolytic anaemia in a young infant transfused with packed red cell. Clin Lab Haematol 3:357–364

  24. 24.

    Placzek MM, Gorst DW (1987) T activation haemolysis and death after blood transfusion. Arch Dis Child 67:73–74

  25. 25.

    Fong JSC, Chadarvian JP de, Kaplan BS (1982) Haemolytic uraemic syndrome: current concepts and management. Pediatr Clin North Am 29:835–856

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Correspondence to Mary E. McGraw.

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McGraw, M.E., Lendon, M., Stevens, R.F. et al. Haemolytic uraemic syndrome and the Thomsen Friedenreich antigen. Pediatr Nephrol 3, 135–139 (1989). https://doi.org/10.1007/BF00852894

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Key words

  • Haemolytic uraemic syndrome
  • Thomsen Friedenreich antigen
  • Pneumococcus