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Separation of racemic phenyl-α- andβ-dialkylamino alcohols into optical isomers

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Conclusions

  1. 1.

    Racemic 1-phenyl-2-dimethylaminoethanol (I) and 1-phenyl-3-dimethylaminopropanol (III) were separated into their optical isomers by fractional crystallization of their diastereoisomeric salts with dibenzoyl-D-tartaric acid.

  2. 2.

    The absolute configuration of the amino alcohols L-(+)-(I) and L-(+)-(II) was determined by a spectropolarimetric method.

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Literature cited

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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2181–2187, October, 1971.

The authors are grateful to E. D. Lubuzh for taking the IR spectra of the amino alcohol and their salts.

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Tomina, L.D., Klabunovskii, E.I., Petrov, Y.I. et al. Separation of racemic phenyl-α- andβ-dialkylamino alcohols into optical isomers. Russ Chem Bull 20, 2063–2067 (1971). https://doi.org/10.1007/BF00851250

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Keywords

  • Alcohol
  • Crystallization
  • Fractional Crystallization
  • Absolute Configuration
  • Optical Isomer