A method was developed for the synthesis of the difficultly accessible, epimeric at the 20-earbon center, 20α,21- and 20β,21-diacetates of the Δ4-isopregnene-17β,20ξ,21-triol-3-ones.
Conditions were selected for the preparative separation of the C-20 epimeric acetonides of A5-isopregnene-3β, 17β,20ξ,21-tetrol, and also of the acetonides of Δ-isopregnene-17β,20ξ,21-triol-3-one.
The structure of all of the synthesized compounds was confirmed by chemical and physical methods.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 1, pp. 136–141, January, 1971.
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Akhrem, A.A., Ustynyuk, T.K. Transformed steroids. Russ Chem Bull 20, 115–119 (1971). https://doi.org/10.1007/BF00849331
- Physical Method
- Preparative Separation