Previous reports on the use of radiolabelled immunoglobulins led us to undertake a pilot experiment in an animal model to investigate the potentials of Tc 99m-immunoglobulin scintigraphy in the detection of infectious foci. Mice infected in one leg with staphylococcus infection were injected with Tc 99m-immunoglobulin, Tc 99m-albumin or gallium citrate Ga 67. The results obtained by scintigraphy suggested a specific accumulation of radiolabelled immunoglobulin at the site of infection. Visualization of the infection and the image quality, especially the 6- and 24-h images, were clearly enhanced after the use of immunoglobulin preparations as compared with gallium.
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Blok, D., Ogtrop, M.v., Arndt, J.W. et al. Detection of inflammatory lesions with radiolabelled immunoglobuline. Eur J Nucl Med 16, 303–305 (1990). https://doi.org/10.1007/BF00842784
- 99mTc labelling