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Restoration of antitumor reactivity of leukocytes of cancer patients after preincubation

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Abstract

Specific antitumor sensitization in patients with gastric cancer was detected by the leukocyte migration inhibition test. After preincubation for 24 h at 4°C in serum-free medium, areactive leukocytes from patients with gastric cancer in stages III–IV reacquired the ability to react specifically to allogenic antigens of a tumor in the same location. Preincubation did not affect inhibition by cancer antigens of migration of leukocytes from patients with noncancerous diseases. The supernatants of preincubated leukocytes from cancer patients contained substances inhibiting migration of the indicator leukocytes.

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Novikov, D.K., Shmakov, A.P. Restoration of antitumor reactivity of leukocytes of cancer patients after preincubation. Bull Exp Biol Med 88, 1176–1178 (1979). https://doi.org/10.1007/BF00838199

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Key Words

  • leukocytes
  • cancer antigens
  • leukocyte migration inhibition