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Possible role of DN-ase I in the development of experimental leukemia

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Increased activity of serum DNase I and of splenic inhibitor of DNase I was found during the development of Friend's virus leukemia. Increased activity of inhibitor in the spleen also was discovered after intravenous injection of exogenous DNase I into mice. The possible role of serum DNase I in the development of experimental leukemia is discussed.

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Drozhennikov, V.A., Perevezentseva, O.S. & Orlova, E.B. Possible role of DN-ase I in the development of experimental leukemia. Bull Exp Biol Med 88, 1159–1162 (1979). https://doi.org/10.1007/BF00838194

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Key Words

  • mouse leukemia
  • DNase I
  • DNase I inhibitor
  • cell proliferation