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Proliferative activity of Švec's tumor after single and repeated irradiation

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Autoradiographic investigations of an experimental tumor after local irradiation in a dose of 600 rad showed no delay in passage of the cells through the cycle at the stages of 6 and 12 h. A marked decrease in mitotic index (MI) and index of labeled nuclei (ILN) was observed 96 h after irradiation. Reirradiation in a dose of 1200 rad after an interval of 18 h led to a marked decrease in MI and ILN through blocking the transition from the G to the S period. By 24–48 h, however, cell proliferation was restored. The high MI found at all times of the investigation after repeated irradiation of the tumor with an interval of 24 h was probably due to an increase in the actual duration of mitosis, as is confirmed by the noticeable increase in the number of the late phases of mitosis.

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Potapov, S.L., Sokolova, L.V. Proliferative activity of Švec's tumor after single and repeated irradiation. Bull Exp Biol Med 80, 1359–1361 (1975).

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Key Words

  • DNA synthesis
  • mitotic activity
  • irradiation