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Dynamics of changes in rat brain and erythrocyte ATPase activity in hypoxic hypoxia

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Abstract

The metabolic action of hypoxia on the enzyme systems of active ion transport depends on the duration of exposure. The activity of Na, K-ATPase is sharply reduced during short periods of hypoxia (15 min) in the microsomes of the brain and in the erythrocytes. With an increase in the exposure to hypoxia an increase in Na, K-ATPase activity is observed (in the erythrocytes after an exposure of 1.5 h in the pressure chamber, in the microsomes after 2 h). The results are evidence of considerable functional changes in the cell membranes during exposure to acute hypoxic hypoxia.

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Govorova, L.V., Aleksandrova, A.E. & Teplov, S.I. Dynamics of changes in rat brain and erythrocyte ATPase activity in hypoxic hypoxia. Bull Exp Biol Med 80, 1308–1310 (1975). https://doi.org/10.1007/BF00835171

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Key Words

  • hypoxic hypoxia
  • brain microsomes
  • erythrocytes
  • Na, K-ATPase