Changes in the liver following penetration by a gastric ulcer were studied in 130 albino rats. Ulcers were produced by Okabe's method. During penetration the capsule of the liver is destroyed and four zones can be distinguished in the tissues of the organ: necrosis, demarcation inflammation, necrobiosis, and proliferation of hepatocytes. Together with destructive processes, in the early stages repair processes developed in the parenchyma and connective-tissue structures. Active proliferation of hepatocytes and of bile ducts leads to their penetration into the granulation tissue at the base of the ulcer. After healing of the ulcer complete restoration of the affected areas of the liver takes place but adhesions with the stomach remain.
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Aruin, L.I., Chikunova, B.Z. & Trubitsyna, I.E. Changes in the liver following penetration by a gastric ulcer (experimental investigation). Bull Exp Biol Med 89, 391–393 (1980). https://doi.org/10.1007/BF00834263
- penetration of the liver by an ulcer
- regeneration of the liver
- proliferation of bile ducts