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Morphological study of some hypothalamic centers in rats after deafferentation of the mediobasal hypothalamus

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Abstract

The volume of the nuclei and nucleoli of certain hypothalamic centers (SON, PVN, SCN, AN, VMN) was determined in control rats and in rats after deafferentation of the mediobasal hypothalamus. Sex differences were found in the parvocellular formations of the control animals: The volumes of nuclei and nucleoli of neurons of AN and VMN, and also of the nucleolus of SCN neurons were larger in females than in males. After deafferentation of the mediobasal hypothalamus the volume of the cell nuclei was increased, especially in hypothalamic formations located outside the isolated zone. This increase was more clearly defined in rats constantly in a state of estrus after the operation. Statistically significant differences between volumes of both nuclei and nucleoli of the cells in subgroups of rats with permanent estrus and with permanent diestrus were found only in the case of SCN. No such differences were found for AN, despite the considerable difference in the constant of luteinizing hormone in the pituitary of the same rats. It is suggested that gonadotropin releasing factors are not produced by the cells of AN and that control over the succession of phases of the sex cycle may be exerted by SCN.

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Ali, G.K.M., Danilova, O.A. Morphological study of some hypothalamic centers in rats after deafferentation of the mediobasal hypothalamus. Bull Exp Biol Med 89, 364–367 (1980). https://doi.org/10.1007/BF00834255

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Key Words

  • mediobasal hypothalamus
  • deafferentation
  • karyometry