Pharmacy World and Science

, Volume 18, Issue 5, pp 163–170 | Cite as

Etoposide phosphate, the water soluble prodrug of etoposide

  • A. H. I. Witterland
  • C. H. W. Koks
  • J. H. Beijnen


Etoposide (Vepesid) is a widely used drug in a variety of neoplasms. To improve the pharmaceutical characteristics of etoposide, etooside phosphate (Etopophos, Bristol-Myers Squibb) has been developed as a prodrug.

Etoposide phosphate is the phosphate ester derivative of etoposide, in comparison to the parent compound, etoposide phosphate is highly soluble in water and can be readily formulated for intravencus uso resulting in higher ctinical application. This paper presents information on the pharmaceutical properties and the current status of etoposide phosphate in clinical triafs.


Alkaline phosphatase Etoposide Etoposide phosphate Mechanism of action Pharmaceutical formulation Pharmacokinetics Prodrug 


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • A. H. I. Witterland
    • 3
  • C. H. W. Koks
    • 3
  • J. H. Beijnen
    • 1
    • 2
  1. 1.Dept. of Medical OncologyAntoni van Leetwenhoek Hospital/The netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.Dept. of Pharmaceutical Analysis & ToxicologyFaculty of PharmacyUtrechtThe Netherlands
  3. 3.Dept. of PharmacySlotervaart Hospital/Netherlands Cancer InstituteAmsterdamThe Netherlands

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