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  • Glycosylation & Disease Section Special Issue — Blood Glycoconjugates As Markers Of Disease
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Transferrin microheterogeneity as a probe in normal and disease states


Isoelectric focusing of iron saturated serum has been established as a convenient method for showing transferrin glycan microheterogeneity. In a clinical setting, the method is used in the detection of cerebrospinal fluid leakage, the screening for surreptitious alcohol abuse and in the diagnosis of the carbohydrate deficient glycoprotein syndrome. In normal physiological states it can also be used as a tool to probe for changes in N-glycosylation.

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Correspondence to H. G. Van Eijk.

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De Jong, G., Feelders, R., Van Noort, W.L. et al. Transferrin microheterogeneity as a probe in normal and disease states. Glycoconjugate J 12, 219–226 (1995). https://doi.org/10.1007/BF00731323

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  • transferrin microheterogeneity
  • isoelectric focusing
  • iron saturated serum
  • cerebrospinal fluid leakage
  • alcohol abuse
  • carbohydrate deficient glycoprotein syndrome
  • N-glycosylation