Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Relative growth of adenomatous polyps of the colon

Stereology and allometry of multiple polyposis

  • 20 Accesses

  • 1 Citations

Summary

The volume of the adenomatous mucosa (V), the area of the surface epithelium (Ss), the area of the glandular epithelium (Sg), and theSg:Ss ratio were calculated in a series of 14 adenomatous polyps (APs) of a case of multiple polyposis of the colon. The equation of simple allometry was used to study the relative growth of the four series of values.Ss grew isometrically with size;Sg overgrewSs and accounted for most of the increase inV. TheSg:Ss ratio increased withSg andV.

This is a preview of subscription content, log in to check access.

References

  1. Cole JW, McKalen A (1963) Studies on the morphogenesis of adenomatous polyps in the human colon. Cancer 16:998–1002

  2. Deschner EE (1983) Adenomas: Preneoplastic events, growth and development in man and experimental systems. Pathol Annu 18 (Part 1):205–219

  3. Elias H, Hyde DM (1983) A guide to practical stereology. Karger, Basel

  4. Elias H, Hyde D, Mullens RS, Lambert FC (1981) Colonic adenomas: Stereology and growth mechanisms. Dis Colon Rectum 24:331–342

  5. Gould SJ (1966) Allometry and size in ontogeny and phylogeny. Biol Rev 41:587–640

  6. Kaye GI, Pascal RR, Lane N (1971) The colonic pericryptal fibroblast sheath: Replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. III. Replication and differentiation in human hyperplasia and adenomatous polyps. Gastroenterology 60:515–536

  7. Lane N, Lev R (1963) Observations on the origin of adenomatous epithelium of the colon. Serial section studies of minute polyps in familial polyposis. Cancer 16:751–764

  8. Maskens AP (1979) Histogenesis of adenomatous polyps in the human large intestine. Gastroenterology 77:1245–1251

  9. Maskens AP, Deschner EE (1977) Tritiated thymidine incorporation into epithelial cells of normal-appearing colorectal mucosa of cancer patients. J Natl Cancer Inst 58:1221–1224

  10. Nakamura S, Kino I (1984) Morphogenesis of minute adenomas in familial polyposis coli. J Natl Cancer Inst 73:41–49

  11. Oohara T, Ogino A, Tohma H (1981) Microscopic adenoma in nonpolyposis coli: Incidence and relation to basal cells and lymphoid follicles. Dis Colon Rectum 24:120–126

  12. Weibel ER (1963) Principles and methods for the morphometric study of the lung and other organs. Lab Invest 12:131–155

  13. Wiebecke B, Krey U, Lohrs U, Eder M (1973) Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchows Arch A 360:179–193

  14. Wiebecke B, Brandts A, Eder M (1974) Epithelial proliferation and morphogenesis of hyperplastic adenomatous and villous polyps of the human colon. Virchows Arch A 364:35–49

Download references

Author information

Correspondence to Carlo M. Pesce.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Pesce, C.M., Colacino, R. Relative growth of adenomatous polyps of the colon. Vichows Archiv A Pathol Anat 412, 151–154 (1987). https://doi.org/10.1007/BF00716187

Download citation

Key words

  • Adenomatous polyps
  • Colon
  • Relative Growth
  • Allometry
  • Morphometry