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Relative growth of adenomatous polyps of the colon

Stereology and allometry of multiple polyposis

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The volume of the adenomatous mucosa (V), the area of the surface epithelium (Ss), the area of the glandular epithelium (Sg), and theSg:Ss ratio were calculated in a series of 14 adenomatous polyps (APs) of a case of multiple polyposis of the colon. The equation of simple allometry was used to study the relative growth of the four series of values.Ss grew isometrically with size;Sg overgrewSs and accounted for most of the increase inV. TheSg:Ss ratio increased withSg andV.

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  1. Cole JW, McKalen A (1963) Studies on the morphogenesis of adenomatous polyps in the human colon. Cancer 16:998–1002

  2. Deschner EE (1983) Adenomas: Preneoplastic events, growth and development in man and experimental systems. Pathol Annu 18 (Part 1):205–219

  3. Elias H, Hyde DM (1983) A guide to practical stereology. Karger, Basel

  4. Elias H, Hyde D, Mullens RS, Lambert FC (1981) Colonic adenomas: Stereology and growth mechanisms. Dis Colon Rectum 24:331–342

  5. Gould SJ (1966) Allometry and size in ontogeny and phylogeny. Biol Rev 41:587–640

  6. Kaye GI, Pascal RR, Lane N (1971) The colonic pericryptal fibroblast sheath: Replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. III. Replication and differentiation in human hyperplasia and adenomatous polyps. Gastroenterology 60:515–536

  7. Lane N, Lev R (1963) Observations on the origin of adenomatous epithelium of the colon. Serial section studies of minute polyps in familial polyposis. Cancer 16:751–764

  8. Maskens AP (1979) Histogenesis of adenomatous polyps in the human large intestine. Gastroenterology 77:1245–1251

  9. Maskens AP, Deschner EE (1977) Tritiated thymidine incorporation into epithelial cells of normal-appearing colorectal mucosa of cancer patients. J Natl Cancer Inst 58:1221–1224

  10. Nakamura S, Kino I (1984) Morphogenesis of minute adenomas in familial polyposis coli. J Natl Cancer Inst 73:41–49

  11. Oohara T, Ogino A, Tohma H (1981) Microscopic adenoma in nonpolyposis coli: Incidence and relation to basal cells and lymphoid follicles. Dis Colon Rectum 24:120–126

  12. Weibel ER (1963) Principles and methods for the morphometric study of the lung and other organs. Lab Invest 12:131–155

  13. Wiebecke B, Krey U, Lohrs U, Eder M (1973) Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchows Arch A 360:179–193

  14. Wiebecke B, Brandts A, Eder M (1974) Epithelial proliferation and morphogenesis of hyperplastic adenomatous and villous polyps of the human colon. Virchows Arch A 364:35–49

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Correspondence to Carlo M. Pesce.

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Pesce, C.M., Colacino, R. Relative growth of adenomatous polyps of the colon. Vichows Archiv A Pathol Anat 412, 151–154 (1987).

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Key words

  • Adenomatous polyps
  • Colon
  • Relative Growth
  • Allometry
  • Morphometry