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Dimethyl dichloromalonate as a new synthetic equivalent of methyl dichloroacetate in the Darzens condensation

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Abstract

Dimethyl dichloromalonate reacts with aldehydes in the presence of sodium methoxide to formα-chloropyruvates,α-chloroglycidates, orα,α-dichlorohydrins, depending on the nature of the aldehyde.

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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1544–1545, August, 1995.

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Berdnikov, E.A., Mamedov, V.A. Dimethyl dichloromalonate as a new synthetic equivalent of methyl dichloroacetate in the Darzens condensation. Russ Chem Bull 44, 1484–1485 (1995). https://doi.org/10.1007/BF00714435

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Key words

  • dimethyl dichloromalonate
  • Darzens reaction
  • α-chloroketones
  • -chloroepoxides
  • α,α-dichlorohydrins