Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Phenol sulfotransferase inheritance

Summary

  1. 1.

    Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of many phenolic and catechol neurotransmitters. Human tissues contain both thermostable (TS) and thermolabile (TL) forms of PST that differ in their substrate specificities, inhibitor sensitivities, physical properties, and regulation.

  2. 2.

    Individual variations in the levels of activity of both TS and TL PST in the human platelet are strongly influenced by inheritance.

  3. 3.

    Individual differences in the level of platelet TS PST activity are correlated with individual variations in the activity of this form of the enzyme in human cerebral cortex, liver, and intestinal mucosa.

  4. 4.

    There are also individual familial differences in the thermal stability of TS PST in the platelet. These differences are correlated with individual variations in the thermal stability of TS PST in cerebral cortex, liver, and intestinal mucosa.

  5. 5.

    Individual variations in the thermal stability of TS PST in hepatic tissue are associated with the presence of one or both of a pair of TS PST isozymes that can be separated by ion-exchange chromatography and that differ in their thermal stabilities.

  6. 6.

    This series of observations suggests that a structural gene polymorphism may be one mechanism by which inheritance controls TS PST in humans. The isozymes of TS PST in liver may represent the products of alternative alleles for this polymorphism, alleles that might control the structure of TS PST in many human tissues.

This is a preview of subscription content, log in to check access.

References

  1. Anderson, R. J., and Jackson, B. L. (1984). Human platelet phenol sulfotransferase: Stability of two forms of the enzyme with time and presence of a racial difference.Clin. Chim. Acta 138185–196.

  2. Campbell, N. R. C., and Weinshilboum, R. (1986). Human phenol sulfotransferase (PST): Correlation of liver and platelet activities.Can. Soc. Clin. Invest. 9(Suppl.):A14.

  3. Campbell, N. R. C., Van Loon, J., and Weinshilboum, R. M. (1987). Human liver phenol sulfotransferase: Assay conditions, biochemical properties and partial purification of isozymes of the thermostable form.Biochem. Pharmacol. 361435–1446.

  4. Häggendal, J. (1963). The presence of conjugated adrenaline and noradrenaline in human blood plasma.Acta Physiol. Scand. 59255–260.

  5. Hart, R. F., Renskers, K. J., Nelson, E. B., and Roth, J. A. (1979). Localization and characterization of phenol sulfotransferase in human platelets.Life Sci. 24125–130.

  6. Langridge, J. (1968). Genetic and enzymatic experiments relating to the tertiary structure ofβ-galactosidase.J. Bacteriol. 961711–1717.

  7. Maidak, B., Campbell, N., and Weinshilboum, R. (1986). Phenol sulfotransferase: correlation of hepatic isozymes with familial thermal stability variants.7th Int. Congr. Hum. Genet., p. 400.

  8. Price, R. A., Cox, N. J., Spielman, R. S., Van Loon, J., Maidak, B. L., and Weinshilboum, R. M. (1987). Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity.Genet. Epidemiol. (in press).

  9. Rein, G., Glover, V., and Sandler, M. (1981). Phenolsulphotransferase in human tissue: Evidence for multiple forms. InPhenolsulfotransferase in Mental Health Research (M. Sandler and E. Usdin, Eds.), Macmillan, London, pp. 98–126.

  10. Rein, G., Glover, V., and Sandler, M. (1982). Multiple forms of phenol-sulfotransferase in human tissues: Selective inhibition by dichloronitrophenol.Biochem. Pharmacol. 311893–1897.

  11. Reiter, C., and Weinshilboum, R. (1982). Acetaminophen and phenol: Substrates for both a thermostable and a thermolabile form of human platelet phenol sulfotransferase.J. Pharmacol. Exp. Ther. 22143–51.

  12. Reiter, C., Mwaluko, G., Dunnette, J., Van Loon, J., and Weinshilboum, R. (1983). Thermolabile and thermostable human platelet phenol sulfotransferase: Substrate specificity and physical separation.Naunyn-Schmied. Arch. Pharmacol. 324140–147.

  13. Reveley, A. M., Carter, S. M. B., Reveley, M. A., and Sandler, M. (1982/1983). A genetic study of platelet phenol sulfotransferase activity in normal and schizophrenic twins.J. Psychiat. Res. 17303–307.

  14. Richter, D. (1940). The inactivation of adrenaline in vivo in man.J. Physiol. (Lond.) 98361–374.

  15. Sundaram, R., and Weinshilboum, R. (1985). Human jejunal phenol sulfotransferase (PST): Partial purification of the “TL” form.Fed. Proc. 441821.

  16. Sundaram, R., Tucker, R., and Weinshilboum, R. (1986). Human phenol sulfotransferase: Correlation of intestinal and platelet activities and thermal stabilities.Clin. Pharmacol. Ther. 39232.

  17. Tyce, G. M., Messick, J. M., Yaksh, T. L., Byer, D. E., Danielson, D. R., and Rorie, D. K. (1986). Amine sulfate formation in the central nervous system.Fed. Proc. 452247–2253.

  18. Van Loon, J., and Weinshilboum, R. M. (1984). Human platelet phenol sulfotransferase: Familial variations in the thermal stability of the TS form.Biochem. Genet. 22997–1014.

  19. Weinshilboum, R. M. (1981). Enzyme thermal stability and population genetic studies: Application to erythrocyte catechol-0-methyltransferase and plasma dopamineβ-hydroxylase. InGenetic Strategies in Psychobiology and Psychiatry (E. S. Gershon, S. Matthysse, X. O. Breakefield, and R. D. Ciaranello, Eds.), Boxwood Press, Pacific Grove, Calif., pp. 79–94.

  20. Weinshilboum, R. M. (1986). Phenol sulfotransferase in humans: Properties, regulation, and function.Fed. Proc. 452223–2228.

  21. Young, W. F., Jr., Okazaki, H., Laws, E. R., Jr., and Weinshilboum, R. M. (1984). Human brain phenol sulfotransferase: Biochemical properties and regional localization.J. Neurochem. 43706–715.

  22. Young, W. F., Jr., Laws, E. R., Jr., Sharbrough, F. W., and Weinshilboum, R. M. (1985). Human phenol sulfotransferase: Correlation of brain and platelet activities.J. Neurochem. 441131–1137.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Weinshilboum, R. Phenol sulfotransferase inheritance. Cell Mol Neurobiol 8, 27–34 (1988). https://doi.org/10.1007/BF00712908

Download citation

Key words

  • phenol sulfotransferase
  • neurotransmitters
  • platelets
  • inheritance control