The effects of prostaglandins on electrical activity of neurons in the canine area postrema were studied using the techniques of extracellular recording with iontophoresis.
Excitatory responses were obtained upon application of prostaglandins A1, B1, B2, E1, F1 α, and F2 α in between 24 and 50% of the cells studied. The excitation was very similar in pattern to that observed to apomorphine, biogenic amines, and several neuropeptides in that it had a relatively long latency, low maimal frequency, and prolonged duration.
Since the area postrema is known to play a central receptive role in initiating emesis to circulating toxins, these results suggest that prostaglandins may play a role in the initiation of some forms of emesis.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Alanzino, G. L., Bradley, P. B., and Wolstencroft, J. H. (1966). Actions of prostaglandins E1, E2 and F2 α on brain stem neurons.Br. J. Pharmacol. Chemother. 27157–163.
Bennett, A., Friedman, C. A., and Vane, J. R. (1967). Release of prostaglandin E1 from the rat stomach.Nature 216873–876.
Bradley, P. B., Samuels, G. M. R., and Shaw, J. E. (1969). Condition of prostaglandin release from the cerebral cortex of cats with the electrocortiogram, following stimulation to the reticular formation.Br. J. Pharmacol. 37151–157.
Brody, M. J., and Kadowitz, P. J. (1974). Prostaglandins are modulators of the autonomic nervous system.Fed. Proc. 3348–60.
Brenner, W. E., Dingfelder, J. R., and Stavrovsky, L. G. (1975). The efficacy and safety of intramuscularly administered 15(s) 15-methylprostaglandin E2 methyl ester for induction of artificial abortion.Am. J. Obstet. Gynecol. 12319.
Burnstock, G., Cocks, T., Paddle, B., and Staszewska-Barczak, J. (1975). Evidence that prostaglandin is responsible for the “rebound contraction” following stimulation of non-adrenergic, non-cholinergic (“purinergic”) inhibitory nerves.Eur. J. Pharmacol. 31360–362.
Carpenter, D. O., Briggs, D. B., and Strominger, N. (1983). Responses of neurons of the canine area postrema to neurotransmitters and peptides.Cell. Mol. Neurobiol. 3113–126.
Carpenter, D. O., Briggs, D. B., Knox, A. P., and Strominger, N. L. (1986). Radiation-induced emesis in the dog: Effects of lesions and drugs.Radiat. Res. (in press).
Chiu, E. K. Y., and Richardson, J. S. (1985). Behavioral and neurochemical aspects of prostaglandins in brain function.Gen. Pharmacol. 16163–175.
Coleman, R. A., Humphrey, P. P. A., Kennedy, I., and Lumley, P. (1984). Prostaglandin receptors—the development of a working classification.Trends Pharmacol. Sci. 5303–306.
Eiler, H., and Paddleford, R. (1979). Induction of intestinal evacuation or vomition (or both) in the dog by prostaglandin F2 α injection: Clinical potential.Am. J. Vet. Res. 40(12):1731–1733.
Gaion, R. M., and Trento, M. (1980). The role of prostacyclin in modulating cholinergic neurotransmission in guinea-pig ileum.Br. J. Pharmacol. 80279–286.
Holmes, S. W. (1970). The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release.Br. J. Pharmacol. 38653–658.
Ito, Y., and Tajima, K. (1979). An electrophysiological analysis of the action of prostaglandin on neuromuscular transmission in the guinea pig vas deferens.J. Physiol. (Lond.)297521–537.
Ito, Y., and Tajima, K. (1981). Actions of indomethacin and prostaglandins on neuro-effector transmission in the dog trachea.J. Physiol. (Lond.)319379–392.
Kaul, A. F., Federschneider, J. M., and Stubblefield, M. D. (1978). A controlled trial of antiemetics in abortion of PGF2 α and Laminaria.J. Reprod. Med. 20(4):213–218.
Kondo, K., Shiniza, T., and Hayaistic, O. (1983). Effects of prostaglandin D2 on membrane potential in neuroblastoma × glioma hybrid cells as determined with a cyanine dye.Biochem. Biophys. Res. Comm. 98648–655.
Ligumsky, M., Goto, Y., Debas, H., and Yamada, T. (1983). Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat.Science 319301–303.
Lippes, J., and Hurd, M. (1975). The use of chlorpromazine and lomotil to prevent and/or reduce the side effects of prostaglandin E2 used for abortion.Contraception 12(5):569–577.
Puurunen, J. (1983). Central nervous system effects of arachidonic acid, PGE2, PGF2 α, PGD2 and PGI2 on gastric secretion in the rat.Br. J. Pharmacol. 80255–262.
Rimele, T. J., and VanHoutte, P. M. (1983). Effects of inhibitors on arachidonic acid metabolism and calcium entry on responses to acetylcholine, potassium, and norepinephrine in the isolated canine saphenous vein.J. Pharmacol. Expl. Ther. 255720–728.
Siggins, G. R., Hoffer, B. J., and Bloom, F. E. (1971). Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. III. Evidence for mediation of norepinephrine effects by cyclic 3′5′adenosine monophosphate.Brain Res. 25535–553.
Trocha, P. J., and Catravas, G. N. (1980). Prostaglandins, lysosomes, and radiation injury. InAdvances in Prostaglandin and Thromboxane Research, Vol. 7 (Samuelson, B., Ramwell, P. W., and Paoletti, R., Eds.), Raven Press, New York, pp. 854–856.
Wang, S.-I. (1980).Physiology and Pharmacology of the Brain Stem, Futura, Mt. Kisco, N.Y.
Willis, J. A., Myers, P. R., and Carpenter, D. O. (1977). An iontophoretic module which controls electroosmosis.J. Eledtrophysiol. Tech. 6817–824.
Yagasaki, O., Funaki, H., and Yanagiya, I. (1984). Contribution of endogenous prostaglandins to excitation of the myenteric plexus of guinea-pig ileum: Are adrenergic factors involved?Eur. J. Pharmacol. 1031–8.
About this article
Cite this article
Briggs, D.B., Carpenter, D.O. Excitation of neurons in the canine area postrema by prostaglandins. Cell Mol Neurobiol 6, 421–426 (1986). https://doi.org/10.1007/BF00711410
- area postrema