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The genomic synteny at DNA level between human and chimpanzee chromosomes

Abstract

The evolutionary relationship between human (Homo sapiens) and chimpanzee (Pan troglodytes) has been the subject of debate and scrutiny for over two decades. The close relationship established by numerous parameters may or may not reflect homology at the DNA level. The recent advent of a molecular method termed the chromosomein situ suppression hybridization (CISS)-technique has prompted us to explore the phylogenetic relationship at the DNA sequence level. Cross-hybridization data using human-derived whole chromosome paints (WCPs) suggests an apparent genomic synteny with chimpanzee chromosomes at the DNA level, thus providing a better understanding of an evolutionary relationship between humans and chimpanzees.

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References

  1. Avarello R, Pedicini A, Caiulo A, Zuffardi O, Fraccaro M (1992) Evidence for an ancestral alphoid domain on the long arm of human chromosome 2.Hum Genet 89: 247–249.

  2. Camerino G, Goodfellow P (1992) Mammalian genetics.Curr Opin Genet Dev 2: 385–386.

  3. deGrouchy J, Turleau C, Finaz C (1978) Chromosomal phylogeny of the primates.Ann Rev Genet 12: 289–327.

  4. deGrouchy J (1987) Chromosome phylogenies of man, great apes and old world monkeys.Genetica 73: 37–52.

  5. Dutrillaux B (1979) Chromosomal evolution in primates: tentative phylogeny fromMicrocebus murinis (Prosimian) to man.Hum Genet 48: 251–314.

  6. Fuscoe JC, Clark LM, Van Dilla MA (1986) Construction of fifteen human chromosome specific DNA libraries from flow purified chromosomes.Cytogenet Cell Genet 43: 79–86.

  7. Hinegardner R (1976). Evolution of genome size. In: Ayala F. ed,Molecular Evolution, Sunderland (Massachussetts): Sinaner Associates Inc.

  8. Hirning U, Schulz WA, Just W, Adolph S, Vogel W (1989) A comparative study of the heterochromatin ofApodemus sylvaticus andApodemus flavicollis.Chromosoma 98: 450–455.

  9. Holmquist GP (1989). Evolution of chromsome bands: molecular ecology of non-coding DNA.Mol Evol 28: 469–486.

  10. Ijdo JW, Baldini A, Ward DC, Reeders ST, Wells RA (1991) Origin of human chromosomes 2: An ancestral telomere-telomere fusion.Proc Natl Acad Sci 88: 9051–9055.

  11. ISCN (1985)An International System for Human Cytogenetic Nomenclature: Birth Defects original Article Series. Vol 21 (1). The National Foundation, New York (1985).

  12. Jorgensen AL, Laursen HB, Jones C, Bak AL (1992) Evolutionarily different alphoid repeat DNA on homologous chromosomes in human and chimpanzee.Proc Natl Acad Sci 89: 3310–3314.

  13. Lander ES (1993) Finding similarities and differences among genomes.Nature Genet 4: 5–6.

  14. Laursen HB, Jorgensen AL, Jones C, Bak AL (1992) Higher rate of evolution of X-chromosome α-repeat DNA in human than in the great apes.EMBO J 11: 2367–2372.

  15. Lejeune J, Dutrillaux B, Rethore MO, Prieur M (1973) Comparison de la structure fine des chromatides d'Homo sapiens et dePan troglodytes.Chromosoma 43: 423–444.

  16. Lichter P, Cremer T, Borden J, Manuelidis L, Ward DC (1988) Delineation of individual human chromosomes in metaphase and interphase cells byin situ suppression hybridization using recombnant DNA libraries.Hum Genet 80: 224–234.

  17. Luke S, Verma RS (1992a) Origin of human chromosome 2.Nature Genet 2: 11–12.

  18. Luke S, Verma RS (1992b) Chromosomal domains of chimpanzee are diverged from human as revealed byin situ hybridization using human genomic probe.Hum Evol 7: 71–74.

  19. Luke S, Verma RS (1993a) Telomeric repeat (TTAGGG)n sequences of human chromosomes are conserved in chimpanzee.Mol Gen Genet 237: 460–462.

  20. Luke S, Verma RS (1993b) Human (Homo sapiens) and chimpanzee (Pan troglodytes) share similar ancestral centromeric alpha satellite DNA sequences but other fractions of heterochromatin differ considerably.Am J Phys Anthropy (in press).

  21. O'Brien SJ, Seuanez HN, Womak JE (1985) On the evolution of genome organization in mammals. In MacIntyre RJ, ed,Molecular Evolutionary Genetics. Plenum Press, New York, pp 519–589.

  22. O'Brien SJ, Seuanez HN, Womack JG (1988) Mammalian genome organization: An evolutionary view.Ann Rev Genet 22: 323–351.

  23. O'Brien SJ, Marshal Graves JA (1990) Report of the committee on comparative gene mapping (HGM 10.5)Cytogenet Cell Genet 55: 406–433.

  24. O'Brien SJ (1993) The genomics generation.Curr Biol 3: 395–397.

  25. Pelliceiari C, Formenti D, Redi CA, Manfredi MG, Romanini MG (1982). DNA content variability in primates.Hum Evol 11: 131–141.

  26. Pinkel D, Lanlegent J, Collins C,et al. (1988) Fluorescencein situ hybridization with human chromosome specific libraries: detection of trisomy 21 and translocations of chromosome 4.Proc Natl Acad Sci 85: 9138–9142.

  27. Sawyer JR (1991) Highly conserved segments in mammalian chromosomes.J Heredity 82: 128–133.

  28. Seuanez HN (1987). The chromosomes of man: Evolutionary considerations. In: Obe G, Basler A, eds.Cytogenetics Springer, Berlin, Heidelberg, New York.

  29. Stanyon R, Weinberg J, Romagno D, Bigon F, Jauch A, Cremer T (1992) Molecular and classical cytogenetic analyses demonstrate an apomorphic reciprocal chromosomal translocation inGorilla gorilla.Am J Phys Anthropol 88: 245–250.

  30. Templeton AR (1982) Genetic architectures of speciation. In: Barigozzi C, ed.Mechanisms of Speciation Alan R. Liss Inc New York, pp 105–121.

  31. Verma RS, Babu A (1989)Human Chromosomes: Manual of Basic Techniques. Pergamon Press, New York.

  32. Van Dilla MA, Deaven LL (1990) Construction of gene libraries for each human chromosome.Cytometry 11: 208–218.

  33. Wienberg J, Jauch A, Stanyon R, Cremer T (1990) Molecular cytotaxonomy of primates by chromosomalin situ suppression hybridization.Genomics 8: 347–350.

  34. Wienberg J, Stanyon R, Jauch A, Cremer T (1992) Homologies in human andMacaca fuscata chromosomes revealed byin situ suppression hybridization with human chromosome specific DNA libraries.Chromosoma 101: 265–270.

  35. Yunis JJ, Sawyer JR, Dunham K (1980) The striking resemblance of high resolution G-banded chromosomes of man and chimpanzee.Science 208: 1145–1148.

  36. Yunis JJ, Prakash O (1982) The origin of man: A chromosomal pictorial legacy.Science 215: 1525–1530.

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Luke, S., Verma, R.S. The genomic synteny at DNA level between human and chimpanzee chromosomes. Chromosome Res 1, 215–219 (1993). https://doi.org/10.1007/BF00710127

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Key words

  • chromosomes
  • CISS-technique
  • genome
  • Pan troglodytes