Serum from rabbits with experimental allergic neuritis (FAN) when injected into rat sciatic nerves produced rapidly evolving demyelination followed by remyelination. Myelinating and non-myelinating Schwann cells as well as myelin itself were damaged by 15 min after injection. Myelin degradation was well advanced prior to involvement by macrophages at 12 h. The demyelinating factor was myelin-specific and complement-dependent. The evidence suggests that the FAN antigen may reside in Schwann cell membranes as well as in myelin.
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Supported by the Medical Research Council of Canada, Grant No. MA-6496 and The Muscular Dystrophy Association of Canada
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Hahn, A.F., Gilbert, J.J. & Feasby, T.E. Passive transfer of demyelination by experimental allergic neuritis serum. Acta Neuropathol 49, 169–176 (1980). https://doi.org/10.1007/BF00707103
- Experimental allergic neuritis
- Humoral immunity
- Schwann cell