Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Phosphoryl amino acids: Common origin for nucleic acids and protein

  • 125 Accesses

  • 35 Citations


A series of compounds (DAP-AA) composed of an amino acid (AA) and a dialkyl phosphoryl group (DAP) is the basic elements of life chemistry. Self-catalysis of DAP-AA gives the self-assembly oligopeptides, even in aqueous medium at 38°C. The oligo-nucleotides could also be assembled from nucleosides' phosphorylation by DAP-AA. DAP-AA acts as the energy source as well as the phosphoryl donor for the synthesis of nuclic Acids and protein. A general expression for the self assembly system is proposed.

This is a preview of subscription content, log in to check access.


  1. 1.

    Fox, S. W. and Dose, K. (1977)Molecular Evolution and the origin of Life, Marcel Dekker, New York.

  2. 2.

    Miller, S. L. and Orgel, L. E. (1974)The Origins of Life on the Earth, Prentice Hall Inc., Englewood Cliffs, New Jersey.

  3. 3.

    Ji, G. J., Xue, C. B., Zeng, J. N., Li, L. P., Chai, W. G. and Zhao, Y. F. (1988) Synthesis of N-O, O-diisopropyl phosphoryl amino acids and dipetides,Synthesis 6, 444–8.

  4. 4.

    Xue, C. B., Yin, Y. W. and Zhao, Y. F. (1988) Studies on Phosphoserine and phosphothreonine derivatives,Tetrahedron Letters, 29, 1145–8.

  5. 5.

    Li, Y. M., Zhang, D. Q., Zhang, H. W., Ji, G. J. and Zhao, Y. F. (1992) B-Carboxyl catalytic effect of N-phosphoryl aspartic acid,Bioorganic Chemistry, 20, 285–295.

  6. 6.

    Li, Y. M., Yin, Y. W. and Zhao, Y. F. (1992) Phosphoryl Group Participation leads to peptide formation from N-phosphoryl amino acids,Int. J. Peptide Protein Res. 39, 375–81.

  7. 7.

    Li, Y. C., Tan, B. and Zhao, Y. F. (1993) Phosphoryl transfer reaction of phosphohistidine,Heteroatom Chemistry, 4, 415–9.

  8. 8.

    Zhao, Y. F., Li, Y. M., Yin, Y. W. and Li, Y. C. (1993) The Regulation Effect of phosphoryl group on amino acids side chain,Science in China, 36, 1453–8.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zhao, Y., Cao, P. Phosphoryl amino acids: Common origin for nucleic acids and protein. J Biol Phys 20, 283–287 (1995). https://doi.org/10.1007/BF00700446

Download citation

Key words

  • basic element of life chemistry
  • model expression
  • phosphoryl amino acids
  • Origin of life