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Phosphoryl amino acids: Common origin for nucleic acids and protein

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Abstract

A series of compounds (DAP-AA) composed of an amino acid (AA) and a dialkyl phosphoryl group (DAP) is the basic elements of life chemistry. Self-catalysis of DAP-AA gives the self-assembly oligopeptides, even in aqueous medium at 38°C. The oligo-nucleotides could also be assembled from nucleosides' phosphorylation by DAP-AA. DAP-AA acts as the energy source as well as the phosphoryl donor for the synthesis of nuclic Acids and protein. A general expression for the self assembly system is proposed.

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Zhao, Y., Cao, P. Phosphoryl amino acids: Common origin for nucleic acids and protein. J Biol Phys 20, 283–287 (1995). https://doi.org/10.1007/BF00700446

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Key words

  • basic element of life chemistry
  • model expression
  • phosphoryl amino acids
  • Origin of life